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Systemic inflammation and residual viraemia in HIV-positive adults on protease inhibitor monotherapy: a cross-sectional study.
Arenas-Pinto, Alejandro; Milinkovic, Ana; Peppa, Dimitra; McKendry, Anna; Maini, Mala; Gilson, Richard.
Afiliación
  • Arenas-Pinto A; Centre for Sexual Health and HIV Research, Research Department of Infection and Population Health, University College London, The Mortimer Market Centre, Off Capper Street, London, WC1E 6JB, UK. A.Arenas-Pinto@ucl.ac.uk.
  • Milinkovic A; MRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, University College London, London, UK. A.Arenas-Pinto@ucl.ac.uk.
  • Peppa D; Centre for Sexual Health and HIV Research, Research Department of Infection and Population Health, University College London, The Mortimer Market Centre, Off Capper Street, London, WC1E 6JB, UK. A.Milinkovic@ucl.ac.uk.
  • McKendry A; The Mortimer Market Centre, Central North West London NHS Foundation Trust, London, UK. dimitra.peppa@nhs.net.
  • Maini M; Research Department of Infection and Immunity, University College London, London, UK. dimitra.peppa@nhs.net.
  • Gilson R; The Mortimer Market Centre, Central North West London NHS Foundation Trust, London, UK. amckendry@doctors.org.uk.
BMC Infect Dis ; 15: 138, 2015 Mar 21.
Article en En | MEDLINE | ID: mdl-25888119
BACKGROUND: Increased levels of markers of systemic inflammation have been associated with serious non-AIDS events even in patients on fully suppressive antiretroviral therapy. We explored residual viremia and systemic inflammation markers in patients effectively treated with ritonavir-boosted protease inhibitor monotherapy (PImono). METHODS: HIV-infected adults with persistent HIV-RNA<50 copies/ml and treated with either a) PImono or b) standard triple-drug cART were recruited for this cross-sectional, exploratory study. Plasma samples were tested for high-sensitivity CRP (hsCRP), Serum Amyloid A (SAA), soluble CD14, IL-6, IL-8 and Cytochrome C. HIV-RNA was measured by real-time PCR (detection limit of 10 copies/ml). RESULTS: 81 patients were recruited (31% on PImono). Two out of 25 (8%) and 3 of 56 (5.4%) patients from the PImono and cART groups respectively had detectable HIV-RNA. Significant correlation between SAA and hsCRP was observed (0.804). No difference between groups was found on prevalence of hsCRP>3 mg/l (21% vs 20% in the PImono and cART groups respectively; p=0.577) or SAA>6.4 mg/l (38% vs 22% in the PImono and cART groups respectively; P=0.172). In a univariate analysis IL6 and IL8 levels were associated with SAA>6.4 mg/l (OR=1.74 and 1.46; 95% CI=1.00-3.03 and 1.06-2.01; p=0.051 and 0.02 respectively) and hsCRP>3 mg/l in (OR=2.00 and 1.37; 95% CI=1.09-3.69 and 1.02-1.85; p=0.026 and 0.039 respectively). CONCLUSIONS: We found no evidence of increased levels of inflammatory biomarkers or higher prevalence of residual viraemia in patients effectively suppressed on PImono as compared with patients on standard cART.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Inhibidores de Proteasas / Viremia / Infecciones por VIH / Ritonavir / Inflamación Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: BMC Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2015 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Inhibidores de Proteasas / Viremia / Infecciones por VIH / Ritonavir / Inflamación Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: BMC Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2015 Tipo del documento: Article