Treatment with 8-OH-modified adenine (TLR7 ligand)-allergen conjugates decreases T helper type 2-oriented murine airway inflammation.

Nencini, Francesca; Pratesi, Sara; Petroni, Giulia; Filì, Lucia; Cardilicchia, Elisa; Casini, Andrea; Occhiato, Ernesto Giovanni; Calosi, Laura; Bani, Daniele; Romagnani, Sergio; Maggi, Enrico; Parronchi, Paola; Vultaggio, Alessandra

Nencini, Francesca; Pratesi, Sara; Petroni, Giulia; Filì, Lucia; Cardilicchia, Elisa; Casini, Andrea; Occhiato, Ernesto Giovanni; Calosi, Laura; Bani, Daniele; Romagnani, Sergio; Maggi, Enrico; Parronchi, Paola; Vultaggio, Alessandra.

Afiliación

Nencini F; Department of Experimental and Clinical Medicine, Centre for Research, Transfer and High Education DENOTHE, Florence, Italy.
Pratesi S; Department of Experimental and Clinical Medicine, Centre for Research, Transfer and High Education DENOTHE, Florence, Italy.
Petroni G; Department of Experimental and Clinical Medicine, Centre for Research, Transfer and High Education DENOTHE, Florence, Italy.
Filì L; Department of Experimental and Clinical Medicine, Centre for Research, Transfer and High Education DENOTHE, Florence, Italy.
Cardilicchia E; Department of Experimental and Clinical Medicine, Centre for Research, Transfer and High Education DENOTHE, Florence, Italy.
Casini A; Department of Chemistry 'Ugo Schiff', University of Florence, Florence, Italy.
Occhiato EG; Department of Chemistry 'Ugo Schiff', University of Florence, Florence, Italy.
Calosi L; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Bani D; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Romagnani S; Department of Experimental and Clinical Medicine, Centre for Research, Transfer and High Education DENOTHE, Florence, Italy.
Maggi E; Department of Experimental and Clinical Medicine, Centre for Research, Transfer and High Education DENOTHE, Florence, Italy.
Parronchi P; Department of Experimental and Clinical Medicine, Centre for Research, Transfer and High Education DENOTHE, Florence, Italy.
Vultaggio A; Immunoallergology Unit, Department of Biomedicine, Careggi Hospital, Florence, Italy.

Immunology ; 145(4): 570-82, 2015 Aug.

Article en En | MEDLINE | ID: mdl-25930741

Asunto(s)

Adenina/farmacología; Alérgenos/farmacología; Antígenos Dermatofagoides/farmacología; Proteínas de Artrópodos/farmacología; Asma/inmunología; Glicoproteínas de Membrana/agonistas; Células Th2/inmunología; Receptor Toll-Like 7/agonistas; Adenina/análogos & derivados; Adenina/inmunología; Alérgenos/inmunología; Animales; Antígenos Dermatofagoides/inmunología; Proteínas de Artrópodos/inmunología; Asma/tratamiento farmacológico; Asma/patología; Lavado Broncoalveolar; Células Cultivadas; Citocinas/genética; Citocinas/inmunología; Pulmón/inmunología; Pulmón/patología; Glicoproteínas de Membrana/genética; Glicoproteínas de Membrana/inmunología; Ratones; Ratones Endogámicos BALB C; Ratones Noqueados; Células Th2/patología; Receptor Toll-Like 7/genética; Receptor Toll-Like 7/inmunología

Palabras clave

adenine derivatives; adjuvants; immunotherapy; toll-like receptors; vaccines

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Asma / Glicoproteínas de Membrana / Alérgenos / Adenina / Células Th2 / Antígenos Dermatofagoides / Receptor Toll-Like 7 / Proteínas de Artrópodos Límite: Animals Idioma: En Revista: Immunology Año: 2015 Tipo del documento: Article País de afiliación: Italia

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