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The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors.
Wieskopf, Jeffrey S; Mathur, Jayanti; Limapichat, Walrati; Post, Michael R; Al-Qazzaz, Mona; Sorge, Robert E; Martin, Loren J; Zaykin, Dmitri V; Smith, Shad B; Freitas, Kelen; Austin, Jean-Sebastien; Dai, Feng; Zhang, Jie; Marcovitz, Jaclyn; Tuttle, Alexander H; Slepian, Peter M; Clarke, Sarah; Drenan, Ryan M; Janes, Jeff; Al Sharari, Shakir; Segall, Samantha K; Aasvang, Eske K; Lai, Weike; Bittner, Reinhard; Richards, Christopher I; Slade, Gary D; Kehlet, Henrik; Walker, John; Maskos, Uwe; Changeux, Jean-Pierre; Devor, Marshall; Maixner, William; Diatchenko, Luda; Belfer, Inna; Dougherty, Dennis A; Su, Andrew I; Lummis, Sarah C R; Imad Damaj, M; Lester, Henry A; Patapoutian, Ardem; Mogil, Jeffrey S.
Afiliación
  • Wieskopf JS; Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec H3A 1B1, Canada.
  • Mathur J; Genomic Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.
  • Limapichat W; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Post MR; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Al-Qazzaz M; Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK.
  • Sorge RE; Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec H3A 1B1, Canada.
  • Martin LJ; Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec H3A 1B1, Canada.
  • Zaykin DV; National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
  • Smith SB; Center for Neurosensory Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Freitas K; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23219, USA.
  • Austin JS; Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec H3A 1B1, Canada.
  • Dai F; Departments of Anesthesiology and Human Genetics, University of Pittsburgh, Pittsburgh, PA 15213, USA.
  • Zhang J; Genomic Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.
  • Marcovitz J; Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec H3A 1B1, Canada.
  • Tuttle AH; Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec H3A 1B1, Canada.
  • Slepian PM; Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec H3A 1B1, Canada.
  • Clarke S; Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec H3A 1B1, Canada.
  • Drenan RM; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.
  • Janes J; Genomic Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.
  • Al Sharari S; Department of Pharmacology, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia.
  • Segall SK; Center for Neurosensory Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Aasvang EK; Section for Surgical Pathophysiology, Rigshospitalet, Copenhagen University, 2100 Copenhagen, Denmark.
  • Lai W; Departments of Anesthesiology and Human Genetics, University of Pittsburgh, Pittsburgh, PA 15213, USA.
  • Bittner R; Department of Surgery, Marienhospital Stuttgart, 70199 Stuttgart, Germany.
  • Richards CI; Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA.
  • Slade GD; Department of Dental Ecology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Kehlet H; Section for Surgical Pathophysiology, Rigshospitalet, Copenhagen University, 2100 Copenhagen, Denmark.
  • Walker J; Genomic Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.
  • Maskos U; Neurobiologie Intégrative des Systèmes Cholinergiques, CNRS UMR 3571, Département de Neuroscience, Institute Pasteur, 75724 Paris, France.
  • Changeux JP; Neurobiologie Intégrative des Systèmes Cholinergiques, CNRS UMR 3571, Département de Neuroscience, Institute Pasteur, 75724 Paris, France.
  • Devor M; Department of Cell and Developmental Biology, Institute of Life Sciences and Center for Research on Pain, Hebrew University of Jerusalem, Jerusalem 91904, Israel.
  • Maixner W; Center for Neurosensory Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Diatchenko L; Center for Neurosensory Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Faculty of Dentistry, Department of Anesthesia, and Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec H3A 1G1, Canada.
  • Belfer I; Departments of Anesthesiology and Human Genetics, University of Pittsburgh, Pittsburgh, PA 15213, USA.
  • Dougherty DA; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Su AI; Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Lummis SC; Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK.
  • Imad Damaj M; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23219, USA.
  • Lester HA; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Patapoutian A; Department of Molecular and Cellular Neuroscience, The Scripps Research Institute, and Howard Hughes Medical Institute, La Jolla, CA 92037, USA.
  • Mogil JS; Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec H3A 1B1, Canada. jeffrey.mogil@mcgill.ca.
Sci Transl Med ; 7(287): 287ra72, 2015 May 13.
Article en En | MEDLINE | ID: mdl-25972004
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Receptores Nicotínicos / Receptores Purinérgicos P2X2 / Receptores Purinérgicos P2X3 / Dolor Crónico Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2015 Tipo del documento: Article País de afiliación: Canadá
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Receptores Nicotínicos / Receptores Purinérgicos P2X2 / Receptores Purinérgicos P2X3 / Dolor Crónico Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2015 Tipo del documento: Article País de afiliación: Canadá