Efficient Radioisotope Energy Transfer by Gold Nanoclusters for Molecular Imaging.
Small
; 11(32): 4002-8, 2015 Aug 26.
Article
en En
| MEDLINE
| ID: mdl-25973916
ABSTRACT
Beta-emitting isotopes Fluorine-18 and Yttrium-90 are tested for their potential to stimulate gold nanoclusters conjugated with blood serum proteins (AuNCs). AuNCs excited by either medical radioisotope are found to be highly effective ionizing radiation energy transfer mediators, suitable for in vivo optical imaging. AuNCs synthesized with protein templates convert beta-decaying radioisotope energy into tissue-penetrating optical signals between 620 and 800 nm. Optical signals are not detected from AuNCs incubated with Technetium-99m, a pure gamma emitter that is used as a control. Optical emission from AuNCs is not proportional to Cerenkov radiation, indicating that the energy transfer between the radionuclide and AuNC is only partially mediated by Cerenkov photons. A direct Coulombic interaction is proposed as a novel and significant mechanism of energy transfer between decaying radionuclides and AuNCs.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Radioisótopos
/
Transferencia de Energía
/
Nanopartículas del Metal
/
Imagen Molecular
/
Oro
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Small
Asunto de la revista:
ENGENHARIA BIOMEDICA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos