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Goldstein-Kac telegraph processes with random speeds: Path probabilities, likelihoods, and reported Lévy flights.
Sim, Aaron; Liepe, Juliane; Stumpf, Michael P H.
Afiliación
  • Sim A; Centre for Integrative Systems Biology and Bioinformatics, Department of Life Sciences, Imperial College London, SW7 2AZ, United Kingdom.
  • Liepe J; Centre for Integrative Systems Biology and Bioinformatics, Department of Life Sciences, Imperial College London, SW7 2AZ, United Kingdom.
  • Stumpf MP; Centre for Integrative Systems Biology and Bioinformatics, Department of Life Sciences, Imperial College London, SW7 2AZ, United Kingdom.
Article en En | MEDLINE | ID: mdl-25974447
ABSTRACT
The Goldstein-Kac telegraph process describes the one-dimensional motion of particles with constant speed undergoing random changes in direction. Despite its resemblance to numerous real-world phenomena, the singular nature of the resultant spatial distribution of each particle precludes the possibility of any a posteriori empirical validation of this random-walk model from data. Here we show that by simply allowing for random speeds, the ballistic terms are regularized and that the diffusion component can be well-approximated via the unscented transform. The result is a computationally efficient yet robust evaluation of the full particle path probabilities and, hence, the parameter likelihoods of this generalized telegraph process. We demonstrate how a population diffusing under such a model can lead to non-Gaussian asymptotic spatial distributions, thereby mimicking the behavior of an ensemble of Lévy walkers.
Asunto(s)
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Bases de datos: MEDLINE Asunto principal: Modelos Teóricos / Movimiento (Física) Tipo de estudio: Clinical_trials / Health_economic_evaluation Idioma: En Revista: Phys Rev E Stat Nonlin Soft Matter Phys Asunto de la revista: BIOFISICA / FISIOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Reino Unido
Buscar en Google
Bases de datos: MEDLINE Asunto principal: Modelos Teóricos / Movimiento (Física) Tipo de estudio: Clinical_trials / Health_economic_evaluation Idioma: En Revista: Phys Rev E Stat Nonlin Soft Matter Phys Asunto de la revista: BIOFISICA / FISIOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Reino Unido