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Synthesis, characterization and in vitro evaluation of a series of novel polyrotaxane-based delivery system for artesunate.
Gong, Xiao-Shun; Jiang, Rui-Jian; Liao, Xia-Li; Xie, Hu-Die; Ma, Xue; Gao, Chuan-Zhu; Yang, Bo; Zhao, Yu-Lin.
Afiliación
  • Gong XS; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, PR China.
  • Jiang RJ; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, PR China.
  • Liao XL; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, PR China.
  • Xie HD; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, PR China.
  • Ma X; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, PR China.
  • Gao CZ; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, PR China.
  • Yang B; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, PR China. Electronic address: yangbo6910@sina.com.
  • Zhao YL; Faculty of Chemical Engineering, Kunming University of Science and Technology, Kunming 650500, PR China. Electronic address: zhaoyulin919@sina.com.
Carbohydr Res ; 412: 7-14, 2015 Aug 14.
Article en En | MEDLINE | ID: mdl-25988495
ABSTRACT
A series of novel artesunate-polyrotaxanes (ATS-PRs) with folic acid capped, in which artesunate (ATS) was covalently bound to a cyclodextrin (CD) of the polyrotaxane (PR), were synthesized and were characterized by NMR, XRD, TG and DSC. The cytotoxicities of ATS-PRs on human colon cancer cell lines HT-29, SW480, HTC116 and DLD-1 showed that their antitumor activities were better than that of artesunate (ATS) and dihydroartemisinin (DHA). These ATS-PRs may provide a useful approach to the development of a highly effective drug candidate for the chemotherapy of human colon cancer.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sistemas de Liberación de Medicamentos / Poloxámero / Ciclodextrinas / Artemisininas / Rotaxanos / Evaluación de Medicamentos Límite: Humans Idioma: En Revista: Carbohydr Res Año: 2015 Tipo del documento: Article
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sistemas de Liberación de Medicamentos / Poloxámero / Ciclodextrinas / Artemisininas / Rotaxanos / Evaluación de Medicamentos Límite: Humans Idioma: En Revista: Carbohydr Res Año: 2015 Tipo del documento: Article