Synthesis, characterization and in vitro evaluation of a series of novel polyrotaxane-based delivery system for artesunate.
Carbohydr Res
; 412: 7-14, 2015 Aug 14.
Article
en En
| MEDLINE
| ID: mdl-25988495
ABSTRACT
A series of novel artesunate-polyrotaxanes (ATS-PRs) with folic acid capped, in which artesunate (ATS) was covalently bound to a cyclodextrin (CD) of the polyrotaxane (PR), were synthesized and were characterized by NMR, XRD, TG and DSC. The cytotoxicities of ATS-PRs on human colon cancer cell lines HT-29, SW480, HTC116 and DLD-1 showed that their antitumor activities were better than that of artesunate (ATS) and dihydroartemisinin (DHA). These ATS-PRs may provide a useful approach to the development of a highly effective drug candidate for the chemotherapy of human colon cancer.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Sistemas de Liberación de Medicamentos
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Poloxámero
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Ciclodextrinas
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Artemisininas
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Rotaxanos
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Evaluación de Medicamentos
Límite:
Humans
Idioma:
En
Revista:
Carbohydr Res
Año:
2015
Tipo del documento:
Article