Prolyl hydroxylase inhibition corrects functional iron deficiency and inflammation-induced anaemia in rats.

Barrett, Terrance D; Palomino, Heather L; Brondstetter, Theresa I; Kanelakis, Kimon C; Wu, Xiaodong; Yan, Wen; Merton, Katherine P; Schoetens, Freddy; Ma, Jing Ying; Skaptason, Judy; Gao, Jingjin; Tran, Da-Thao; Venkatesan, Hariharan; Rosen, Mark D; Shankley, Nigel P; Rabinowitz, Michael H

Barrett, Terrance D; Palomino, Heather L; Brondstetter, Theresa I; Kanelakis, Kimon C; Wu, Xiaodong; Yan, Wen; Merton, Katherine P; Schoetens, Freddy; Ma, Jing Ying; Skaptason, Judy; Gao, Jingjin; Tran, Da-Thao; Venkatesan, Hariharan; Rosen, Mark D; Shankley, Nigel P; Rabinowitz, Michael H.

Afiliación

Barrett TD; Cardiovascular Metabolic Research, Janssen Pharmaceutical Companies of Johnson & Johnson, San Diego, CA, USA.
Palomino HL; School of Medicine, University of California at San Diego, San Diego, CA, USA.
Brondstetter TI; Covenant Care, Palo Alto, CA, USA.
Kanelakis KC; Office of Foods and Veterinary Medicine, U.S. Food and Drug Administration, Rockville, MD, USA.
Wu X; Cardiovascular Metabolic Research, Janssen Pharmaceutical Companies of Johnson & Johnson, San Diego, CA, USA.
Yan W; Arcturus Therapeutics, San Diego, CA, USA.
Merton KP; Cardiovascular Metabolic Research, Janssen Pharmaceutical Companies of Johnson & Johnson, San Diego, CA, USA.
Schoetens F; Cardiovascular Metabolic Research, Janssen Pharmaceutical Companies of Johnson & Johnson, San Diego, CA, USA.
Ma JY; Cardiovascular Metabolic Research, Janssen Pharmaceutical Companies of Johnson & Johnson, San Diego, CA, USA.
Skaptason J; Cardiovascular Metabolic Research, Janssen Pharmaceutical Companies of Johnson & Johnson, San Diego, CA, USA.
Gao J; Cardiovascular Metabolic Research, Janssen Pharmaceutical Companies of Johnson & Johnson, San Diego, CA, USA.
Tran DT; Cardiovascular Metabolic Research, Janssen Pharmaceutical Companies of Johnson & Johnson, San Diego, CA, USA.
Venkatesan H; Cardiovascular Metabolic Research, Janssen Pharmaceutical Companies of Johnson & Johnson, San Diego, CA, USA.
Rosen MD; Aetheria Therapeutics, San Diego, CA, USA.
Shankley NP; Higher Todsworthy Farm, Cornwall, UK.
Rabinowitz MH; Aetheria Therapeutics, San Diego, CA, USA.

Br J Pharmacol ; 172(16): 4078-88, 2015 Aug.

Article en En | MEDLINE | ID: mdl-25988595

Asunto(s)

Anemia/tratamiento farmacológico; Inhibidores de Prolil-Hidroxilasa/uso terapéutico; Pirazoles/uso terapéutico; Quinazolinonas/uso terapéutico; Anemia/sangre; Anemia/genética; Anemia/metabolismo; Animales; Proteínas de Transporte de Catión/genética; Citocromos b/genética; Duodeno/efectos de los fármacos; Duodeno/metabolismo; Índices de Eritrocitos/efectos de los fármacos; Eritropoyetina/sangre; Eritropoyetina/genética; Eritropoyetina/farmacología; Eritropoyetina/uso terapéutico; Femenino; Expresión Génica/efectos de los fármacos; Hemoglobinas/análisis; Inflamación/sangre; Inflamación/inducido químicamente; Inflamación/complicaciones; Inflamación/genética; Inflamación/metabolismo; Hierro/sangre; Riñón/efectos de los fármacos; Riñón/metabolismo; Hígado/efectos de los fármacos; Hígado/metabolismo; Peptidoglicano; Inhibidores de Prolil-Hidroxilasa/farmacocinética; Inhibidores de Prolil-Hidroxilasa/farmacología; Pirazoles/farmacocinética; Pirazoles/farmacología; Quinazolinonas/farmacocinética; Quinazolinonas/farmacología; Ratas Endogámicas Lew

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Pirazoles / Quinazolinonas / Inhibidores de Prolil-Hidroxilasa / Anemia Idioma: En Revista: Br J Pharmacol Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google