Your browser doesn't support javascript.
loading
Increased Vancomycin Susceptibility in Mycobacteria: a New Approach To Identify Synergistic Activity against Multidrug-Resistant Mycobacteria.
Soetaert, Karine; Rens, Céline; Wang, Xiao-Ming; De Bruyn, Jacqueline; Lanéelle, Marie-Antoinette; Laval, Françoise; Lemassu, Anne; Daffé, Mamadou; Bifani, Pablo; Fontaine, Véronique; Lefèvre, Philippe.
Afiliación
  • Soetaert K; Scientific Institute of Public Health (WIV-ISP), Operational Direction of Communicable and Infectious Diseases, Brussels, Belgium.
  • Rens C; Université Libre de Bruxelles (ULB), Unit of Pharmaceutical Microbiology and Hygiene, Brussels, Belgium.
  • Wang XM; Scientific Institute of Public Health (WIV-ISP), Operational Direction of Communicable and Infectious Diseases, Brussels, Belgium.
  • De Bruyn J; Université Libre de Bruxelles (ULB), Unit of Pharmaceutical Microbiology and Hygiene, Brussels, Belgium.
  • Lanéelle MA; Tuberculosis and Infection Biology (TBIB), Institute of Pharmacology and Structural Biology of CNRS and the University Paul Sabatier (UMR 5089), Toulouse, France.
  • Laval F; Tuberculosis and Infection Biology (TBIB), Institute of Pharmacology and Structural Biology of CNRS and the University Paul Sabatier (UMR 5089), Toulouse, France.
  • Lemassu A; Tuberculosis and Infection Biology (TBIB), Institute of Pharmacology and Structural Biology of CNRS and the University Paul Sabatier (UMR 5089), Toulouse, France.
  • Daffé M; Tuberculosis and Infection Biology (TBIB), Institute of Pharmacology and Structural Biology of CNRS and the University Paul Sabatier (UMR 5089), Toulouse, France.
  • Bifani P; Novartis Institute for Tropical Diseases (NITD), Singapore, Singapore.
  • Fontaine V; Université Libre de Bruxelles (ULB), Unit of Pharmaceutical Microbiology and Hygiene, Brussels, Belgium.
  • Lefèvre P; Université Libre de Bruxelles (ULB), Unit of Pharmaceutical Microbiology and Hygiene, Brussels, Belgium philefev@ulb.ac.be.
Antimicrob Agents Chemother ; 59(8): 5057-60, 2015 Aug.
Article en En | MEDLINE | ID: mdl-26033733
Mycobacterium tuberculosis is wrapped in complex waxes, impermeable to most antibiotics. Comparing Mycobacterium bovis BCG and M. tuberculosis mutants that lack phthiocerol dimycocerosates (PDIM) and/or phenolic glycolipids with wild-type strains, we observed that glycopeptides strongly inhibited PDIM-deprived mycobacteria. Vancomycin together with a drug targeting lipid synthesis inhibited multidrug-resistant (MDR) and extensively drug-resistant (XDR) clinical isolates. Our study puts glycopeptides in the pipeline of potential antituberculosis (TB) agents and might provide a new antimycobacterial drug-screening strategy.
Asunto(s)
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Glicopéptidos / Vancomicina / Mycobacterium bovis / Mycobacterium tuberculosis / Antituberculosos Límite: Humans Idioma: En Revista: Antimicrob Agents Chemother Año: 2015 Tipo del documento: Article País de afiliación: Bélgica
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Glicopéptidos / Vancomicina / Mycobacterium bovis / Mycobacterium tuberculosis / Antituberculosos Límite: Humans Idioma: En Revista: Antimicrob Agents Chemother Año: 2015 Tipo del documento: Article País de afiliación: Bélgica