Effect of atovastatin treatment on porcine circovirus 2 infection in BALB/c mice.
Clin Exp Pharmacol Physiol
; 42(8): 817-21, 2015 Aug.
Article
en En
| MEDLINE
| ID: mdl-26041431
ABSTRACT
The HMG-CoA reductase (HMGCR) pathway is an important metabolic route, which is not only present in almost every organism, but also involves virus infection. It has recently been shown that expression levels of IFN-responsive genes were significantly increased in HMGCR-downregulated cells and HMGCR inhibitor-treated cells. The aim of this study was to determine whether inhibition of HMGCR by atovastatin would significantly affect Porcine circovirus type 2 (PCV2) infection and immunological reaction in BALB/c mice. The results showed atovastatin significantly stimulated PCV2 replication in vivo. Immunological reaction in atovastatin-treated mice was also significantly enhanced during PCV2 infection. Atovastatin also enhanced PCV2-induced illness in mice. The results of this study will provide new insight into the role of atovastatin in PCV2 infection.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Circovirus
/
Infecciones por Circoviridae
/
Atorvastatina
Límite:
Animals
Idioma:
En
Revista:
Clin Exp Pharmacol Physiol
Año:
2015
Tipo del documento:
Article
País de afiliación:
China