A Newly Emerged Swine-Origin Influenza A(H3N2) Variant Dampens Host Antiviral Immunity but Induces Potent Inflammasome Activation.
J Infect Dis
; 212(12): 1923-9, 2015 Dec 15.
Article
en En
| MEDLINE
| ID: mdl-26068782
ABSTRACT
We compared the innate immune response to a newly emerged swine-origin influenza A(H3N2) variant containing the M gene from 2009 pandemic influenza A(H1N1), termed "A(H3N2)vpM," to the immune responses to the 2010 swine-origin influenza A(H3N2) variant and seasonal influenza A(H3N2). Our results demonstrated that A(H3N2)vpM-induced myeloid dendritic cells secreted significantly lower levels of type I interferon (IFN) but produced significantly higher levels of proinflammatory cytokines and induced potent inflammasome activation. The reduction in antiviral immunity with increased inflammatory responses upon A(H3N2)vpM infection suggest that these viruses have the potential for increased disease severity in susceptible hosts.
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Bases de datos:
MEDLINE
Asunto principal:
Leucocitos Mononucleares
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Subtipo H1N1 del Virus de la Influenza A
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Subtipo H3N2 del Virus de la Influenza A
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Inflamasomas
Límite:
Animals
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Humans
Idioma:
En
Revista:
J Infect Dis
Año:
2015
Tipo del documento:
Article