Monitoring of Ebola Virus Makona Evolution through Establishment of Advanced Genomic Capability in Liberia.
Emerg Infect Dis
; 21(7): 1135-43, 2015 Jul.
Article
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| MEDLINE
| ID: mdl-26079255
ABSTRACT
To support Liberia's response to the ongoing Ebola virus (EBOV) disease epidemic in Western Africa, we established in-country advanced genomic capabilities to monitor EBOV evolution. Twenty-five EBOV genomes were sequenced at the Liberian Institute for Biomedical Research, which provided an in-depth view of EBOV diversity in Liberia during September 2014-February 2015. These sequences were consistent with a single virus introduction to Liberia; however, shared ancestry with isolates from Mali indicated at least 1 additional instance of movement into or out of Liberia. The pace of change is generally consistent with previous estimates of mutation rate. We observed 23 nonsynonymous mutations and 1 nonsense mutation. Six of these changes are within known binding sites for sequence-based EBOV medical countermeasures; however, the diagnostic and therapeutic impact of EBOV evolution within Liberia appears to be low.
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Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Fiebre Hemorrágica Ebola
/
Ebolavirus
Límite:
Humans
País/Región como asunto:
Africa
Idioma:
En
Revista:
Emerg Infect Dis
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
Año:
2015
Tipo del documento:
Article