An Unusual Presentation of Disseminated Histoplasmosis: Case Report and Review of Pediatric Immunocompetent Patients from India.
Mycopathologia
; 180(5-6): 359-64, 2015 Dec.
Article
en En
| MEDLINE
| ID: mdl-26126955
ABSTRACT
Histoplasmosis is a progressive disease caused by dimorphic intracellular fungi and can prove fatal. Usually, it is present in immunocompromised individuals and immunocompetent individuals in the endemic zones. We report an unusual presentation of progressive disseminated histoplasmosis. The patient in the present case report was immunocompetent child and had fever, bone pains, gradual weight loss, lymphadenopathy and hepatosplenomegaly. Disseminated histoplasmosis (DH) was diagnosed on microscopic examination and fungal culture of bone marrow, blood, skin biopsy and lymph node aspirate. The patient died on seventh day of amphotericin B. In the absence of predisposing factors and classical clinical presentation of febrile neutropenia, lung, adrenal and oropharyngeal lesions, the disease posed a diagnostic challenge. Progressive disseminated histoplasmosis in children can be fatal despite timely diagnosis and therapy. In India, disseminated histoplasmosis is seen in immunocompetent hosts. All the pediatrics immunocompetent cases from India are also reviewed.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Fungemia
/
Histoplasma
/
Histoplasmosis
Límite:
Child
/
Female
/
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Mycopathologia
Año:
2015
Tipo del documento:
Article
País de afiliación:
India