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Antibacterial Δ(1) -3-ketosteroids from the South China Sea gorgonian coral Subergorgia rubra.
Sun, Xue-Ping; Cao, Fei; Shao, Chang-Lun; Wang, Mei; Zhang, Xiu-Li; Wang, Chang-Yun.
Afiliación
  • Sun XP; Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P. R. China, (phone: +86-532-82031536; fax: +86-532-82031536 ext. 266003).
  • Cao F; Guangxi Key Laboratory of Marine Biotechnology, Guangxi Institute of Oceanology, Beihai 536000, P. R. China.
  • Shao CL; Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P. R. China, (phone: +86-532-82031536; fax: +86-532-82031536 ext. 266003).
  • Wang M; Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P. R. China, (phone: +86-532-82031536; fax: +86-532-82031536 ext. 266003).
  • Zhang XL; Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P. R. China, (phone: +86-532-82031536; fax: +86-532-82031536 ext. 266003).
  • Wang CY; Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P. R. China, (phone: +86-532-82031536; fax: +86-532-82031536 ext. 266003).
Chem Biodivers ; 12(7): 1068-74, 2015 Jul.
Article en En | MEDLINE | ID: mdl-26172327
ABSTRACT
Three new Δ(1) -3-ketosteroids characterized with a 9-OH, subergosterones A-C (1-3), together with five known analogs 4-8, were obtained from the gorgonian coral Subergorgia rubra collected from the South China Sea. The structures of 1-3, including their absolute configurations, were determined by comprehensive spectroscopic methods and electronic circular dichroism (ECD) experiments. Compounds 2 and 3 exhibited inhibitory antibacterial activities against Bacillus cereus with MIC values of 1.56 µM.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Bacillus cereus / Antozoos / Cetosteroides / Antibacterianos Límite: Animals Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Bacillus cereus / Antozoos / Cetosteroides / Antibacterianos Límite: Animals Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article