Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3α.
Sci Rep
; 5: 12698, 2015 Aug 03.
Article
en En
| MEDLINE
| ID: mdl-26237540
ABSTRACT
Hypoxia-inducible transcription factors (HIF) form heterodimeric complexes that mediate cell responses to hypoxia. The oxygen-dependent stability and activity of the HIF-α subunits is traditionally associated to post-translational modifications such as hydroxylation, acetylation, ubiquitination, and phosphorylation. Here we report novel evidence showing that unsaturated fatty acids are naturally occurring, non-covalent structural ligands of HIF-3α, thus providing the initial framework for exploring its exceptional role as a lipid sensor under hypoxia.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Ácido Oléico
/
Ácido Linoleico
/
Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico
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Neoplasias
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Sci Rep
Año:
2015
Tipo del documento:
Article