T Cell Adolescence: Maturation Events Beyond Positive Selection.
J Immunol
; 195(4): 1351-7, 2015 Aug 15.
Article
en En
| MEDLINE
| ID: mdl-26254267
ABSTRACT
Single-positive thymocytes that successfully complete positive and negative selection must still undergo one final step, generally termed T cell maturation, before they gain functional competency and enter the long-lived T cell pool. Maturation initiates after positive selection in single-positive thymocytes and continues in the periphery in recent thymic emigrants, before these newly produced T cells gain functional competency and are ready to participate in the immune response as peripheral naive T cells. Recent work using genetically altered mice demonstrates that T cell maturation is not a single process, but a series of steps that occur independently and sequentially after positive selection. This review focuses on the changes that occur during T cell maturation, as well as the molecules and pathways that are critical at each step.
Texto completo:
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Bases de datos:
MEDLINE
Asunto principal:
Linfocitos T
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Receptores de Muerte Celular
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Timocitos
Límite:
Animals
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Humans
Idioma:
En
Revista:
J Immunol
Año:
2015
Tipo del documento:
Article