Effect of clozapine on locomotor activity and anxiety-related behavior in the neonatal mice administered MK-801.
Bosn J Basic Med Sci
; 15(3): 74-9, 2015 Aug 11.
Article
en En
| MEDLINE
| ID: mdl-26295298
ABSTRACT
Atypical antipsychotics have been used to treat fear and anxiety disturbance that are highly common in schizophrenic patients. It is suggested that disruptions of N-methyl-d-aspartate (NMDA)-mediated transmission of glutamate may underlie the pathophysiology of schizophrenia. The present study was conducted to analyze the effectiveness of clozapine on the anxiety-related behavior and locomotor function of the adult brain, which had previously undergone NMDA receptor blockade during a developmental period. In order to block the NMDA receptor, male mice were administered 0.25 mg/kg of MK-801 on days 7 to 10 postnatal. In adulthood, they were administered intraperitoneally 0.5 mg/kg of clozapine and tested with open-field and elevated plus maze test, to assess their emotional behavior and locomotor activity. In the group receiving MK-801 in the early developmental period the elevated plus maze test revealed a reduction in the anxiety-related behavior (p<0.05), while the open-field test indicated a decrease in locomotor activity (p<0.01). Despite these reductions, clozapine could not reverse the NMDA receptor blockade. Also, as an atypical antipsychotic agent, clozapine could not reverse impairment in the locomotor activity and anxiety-related behavior, induced by administration of the MK-801 in neonatal period.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Ansiedad
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Conducta Animal
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Maleato de Dizocilpina
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Clozapina
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Antagonistas de Aminoácidos Excitadores
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Actividad Motora
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Bosn J Basic Med Sci
Asunto de la revista:
MEDICINA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Turquía