Effect of a single bolus of dexamethasone on intraoperative and postoperative pain in unilateral inguinal hernia surgery.
J Anaesthesiol Clin Pharmacol
; 31(3): 339-43, 2015.
Article
en En
| MEDLINE
| ID: mdl-26330712
ABSTRACT
BACKGROUND AND AIMS:
Opioids are commonly used to provide perioperative analgesia, but have many side-effects. Addition of co-analgesics results in reducing the dosage and hence the side-effects of opioids. The objective of this study was to compare the analgesic efficacy of fentanyl (1 micro/kg(-1)) administered alone, with fentanyl (0.75 micro/kg(-1)) and dexamethasone (8 mg) combination, in patients undergoing day care unilateral inguinal hernia repair. MATERIAL ANDMETHODS:
Patients scheduled for the day care unilateral inguinal hernia repair were randomized to receive either saline and fentanyl 1 micro/kg(-1) (control group) or 8 mg dexamethasone with fentanyl 0.75 micro/kg(-1) (study group) immediately before induction of anesthesia in a double-blind clinical trial. Anesthesia technique and rescue analgesia regimen were standardized. Intraoperatively, pain was assessed based on hemodynamic variability and postoperatively by visual analog scale.RESULTS:
The mean heart rate, systolic and the diastolic blood pressure at 1, 5, 20 and at 30 min after incision, were significantly higher in the control group (P ≤ 0.001) when compared to the study group. Intra-operative rescue analgesia was required in 32 (100%) and 19 (59.4%) patients in control group and study group respectively (P = 0.0002). Mean pain scores measured at fixed time periods postoperatively were significantly higher in the control group when compared to study group (P ≤ 0.001). Postoperative rescue analgesia was needed in 32 (100%) versus 24 (75%) patients in the control group and study group respectively, but this difference was not statistically significant (P = 0.285).CONCLUSION:
We conclude that the addition of 8 mg of preoperative intravenous dexamethasone to 0.75 micro/kg(-1) fentanyl was effective in reducing intraoperative and postoperative pain in the 1(st) h after unilateral inguinal hernia surgery.
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Bases de datos:
MEDLINE
Tipo de estudio:
Clinical_trials
Idioma:
En
Revista:
J Anaesthesiol Clin Pharmacol
Año:
2015
Tipo del documento:
Article
País de afiliación:
Pakistán