Inner hair cell ribbon synapse plasticity might be molecular basis of temporary hearing threshold shifts in mice.
Int J Clin Exp Pathol
; 8(7): 8680-91, 2015.
Article
en En
| MEDLINE
| ID: mdl-26339457
ABSTRACT
Recent studies have reported that noise exposure at relatively low intensities can cause temporary threshold shifts (TTS) in hearing. However, the mechanism underlying the TTS is still on debate. Here, we report that an acoustic stimulation (100 dB SPL, white noise) induced TTS in mice, with the maximal ABR threshold elevations seen on the 4(th) day after noise exposure. On the other hand, there were no significant morphological changes in the cochlea. Further, there were paralleled changes of pre-synaptic ribbons in both the number and postsynaptic density (PSDs) during this noise exposure. The numbers of presynaptic ribbon, postsynaptic density (PSDs), and colocalized puncta correlated with the shifts of ABR thresholds. Moreover, a complete recovery of ABR thresholds and synaptic puncta was seen on the 14(th) day after the noise stimulations. Thus, our study may indicate that noise exposure can cause a decline in cochlear ribbon synapses and result in consequent hearing loss. The reduction of synaptic puncta appears reversible and may contribute to hearing restoration in mice after noise exposure.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Fatiga Auditiva
/
Sinapsis
/
Células Ciliadas Auditivas Internas
/
Pérdida Auditiva Provocada por Ruido
/
Plasticidad Neuronal
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Int J Clin Exp Pathol
Asunto de la revista:
PATOLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
China