The effect of vitamin E on glycosylated hemoglobin levels in diabetic rats: a preliminary report.
Diabetes Res
; 12(3): 123-4, 1989 Nov.
Article
en En
| MEDLINE
| ID: mdl-2635093
The effect of vitamin E (D-alpha-tocopherol acetate) on glycosylated hemoglobin levels was investigated in streptozotocin-diabetic rats. The animals were divided into four groups: (a) Group 1: control group, (b) Group 2: diabetic group, (c) Group 3: diabetic group treated with low-dose vitamin E and (d) Group 4: diabetic group treated with high-dose vitamin E. Starting 24 hr after streptozotocin injections (60 mg/kg), Groups 3 and 4 received intraperitoneal injections of vitamin E on days 1, 4, 7, 11, 14, 18 and 21 at doses of 500 mg/kg and 1,000 mg/kg respectively. Vitamin E treatment did not prevent weight loss or improve glycemic control in diabetic animals but significantly suppressed the increase in glycosylated hemoglobin in Group 4 (7.7 +/- 0.6 mumols fructose/g hemoglobin versus 5.5 +/- 0.2 mumols fructose/g hemoglobin in Group 2 and Group 4 respectively). These levels were still significantly higher than the levels in healthy control group animals (2.6 +/- 0.1 mumols fructose/g hemoglobin). Further studies on the suppressive effect of vitamin E are warranted.
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Bases de datos:
MEDLINE
Asunto principal:
Vitamina E
/
Hemoglobina Glucada
/
Diabetes Mellitus Experimental
Límite:
Animals
Idioma:
En
Revista:
Diabetes Res
Asunto de la revista:
ENDOCRINOLOGIA
Año:
1989
Tipo del documento:
Article
País de afiliación:
Turquía