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Time-Dependent Inhibition of CYP2C19 by Isoquinoline Alkaloids: In Vitro and In Silico Analysis.
Salminen, Kaisa A; Rahnasto-Rilla, Minna; Väänänen, Raija; Imming, Peter; Meyer, Achim; Horling, Aline; Poso, Antti; Laitinen, Tuomo; Raunio, Hannu; Lahtela-Kakkonen, Maija.
Afiliación
  • Salminen KA; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland (K.A.S., M.R.-R., R.V., A.P., T.L., H.R., M.L.-K.); and Institut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany (P.I., A.M., A.H.) kaisa.salminen@uef.fi.
  • Rahnasto-Rilla M; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland (K.A.S., M.R.-R., R.V., A.P., T.L., H.R., M.L.-K.); and Institut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany (P.I., A.M., A.H.).
  • Väänänen R; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland (K.A.S., M.R.-R., R.V., A.P., T.L., H.R., M.L.-K.); and Institut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany (P.I., A.M., A.H.).
  • Imming P; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland (K.A.S., M.R.-R., R.V., A.P., T.L., H.R., M.L.-K.); and Institut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany (P.I., A.M., A.H.).
  • Meyer A; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland (K.A.S., M.R.-R., R.V., A.P., T.L., H.R., M.L.-K.); and Institut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany (P.I., A.M., A.H.).
  • Horling A; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland (K.A.S., M.R.-R., R.V., A.P., T.L., H.R., M.L.-K.); and Institut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany (P.I., A.M., A.H.).
  • Poso A; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland (K.A.S., M.R.-R., R.V., A.P., T.L., H.R., M.L.-K.); and Institut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany (P.I., A.M., A.H.).
  • Laitinen T; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland (K.A.S., M.R.-R., R.V., A.P., T.L., H.R., M.L.-K.); and Institut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany (P.I., A.M., A.H.).
  • Raunio H; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland (K.A.S., M.R.-R., R.V., A.P., T.L., H.R., M.L.-K.); and Institut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany (P.I., A.M., A.H.).
  • Lahtela-Kakkonen M; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland (K.A.S., M.R.-R., R.V., A.P., T.L., H.R., M.L.-K.); and Institut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany (P.I., A.M., A.H.).
Drug Metab Dispos ; 43(12): 1891-904, 2015 Dec.
Article en En | MEDLINE | ID: mdl-26400396
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Simulación por Computador / Extractos Vegetales / Alcaloides / Citocromo P-450 CYP2C19 / Inhibidores del Citocromo P-450 CYP2C19 / Isoquinolinas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Drug Metab Dispos Asunto de la revista: FARMACOLOGIA Año: 2015 Tipo del documento: Article
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Simulación por Computador / Extractos Vegetales / Alcaloides / Citocromo P-450 CYP2C19 / Inhibidores del Citocromo P-450 CYP2C19 / Isoquinolinas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Drug Metab Dispos Asunto de la revista: FARMACOLOGIA Año: 2015 Tipo del documento: Article