Your browser doesn't support javascript.
loading
Prenatal testosterone exposure is related to sexually dimorphic facial morphology in adulthood.
Whitehouse, Andrew J O; Gilani, Syed Zulqarnain; Shafait, Faisal; Mian, Ajmal; Tan, Diana Weiting; Maybery, Murray T; Keelan, Jeffrey A; Hart, Roger; Handelsman, David J; Goonawardene, Mithran; Eastwood, Peter.
Afiliación
  • Whitehouse AJ; Telethon Kids Institute, University of Western Australia, 100 Roberts Road, Subiaco, Perth, Western Australia 6008, Australia andrew.whitehouse@telethonkids.org.au.
  • Gilani SZ; School of Computer Science and Software Engineering, University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009, Australia.
  • Shafait F; School of Computer Science and Software Engineering, University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009, Australia School of Electrical Engineering and Computer Science, National University of Science and Technology, Islamabad, Pakistan.
  • Mian A; School of Computer Science and Software Engineering, University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009, Australia.
  • Tan DW; Telethon Kids Institute, University of Western Australia, 100 Roberts Road, Subiaco, Perth, Western Australia 6008, Australia Neurocognitive Development Unit, School of Psychology, University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009, Australia.
  • Maybery MT; Neurocognitive Development Unit, School of Psychology, University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009, Australia.
  • Keelan JA; School of Women's and Infants' Health, University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009, Australia.
  • Hart R; School of Women's and Infants' Health, University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009, Australia.
  • Handelsman DJ; ANZAC Research Institute, University of Sydney, Concord Hospital, New South Wales 2139, Australia.
  • Goonawardene M; School of Dentistry/Oral Health Centre of Western Australia, University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009, Australia.
  • Eastwood P; Centre for Sleep Science, School of Anatomy, Physiology and Human Biology, University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009, Australia.
Proc Biol Sci ; 282(1816): 20151351, 2015 10 07.
Article en En | MEDLINE | ID: mdl-26400740
Prenatal testosterone may have a powerful masculinizing effect on postnatal physical characteristics. However, no study has directly tested this hypothesis. Here, we report a 20-year follow-up study that measured testosterone concentrations from the umbilical cord blood of 97 male and 86 female newborns, and procured three-dimensional facial images on these participants in adulthood (range: 21-24 years). Twenty-three Euclidean and geodesic distances were measured from the facial images and an algorithm identified a set of six distances that most effectively distinguished adult males from females. From these distances, a 'gender score' was calculated for each face, indicating the degree of masculinity or femininity. Higher cord testosterone levels were associated with masculinized facial features when males and females were analysed together (n = 183; r = -0.59), as well as when males (n = 86; r = -0.55) and females (n = 97; r = -0.48) were examined separately (p-values < 0.001). The relationships remained significant and substantial after adjusting for potentially confounding variables. Adult circulating testosterone concentrations were available for males but showed no statistically significant relationship with gendered facial morphology (n = 85, r = 0.01, p = 0.93). This study provides the first direct evidence of a link between prenatal testosterone exposure and human facial structure.
Asunto(s)
Palabras clave

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Testosterona / Cara / Sangre Fetal Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Pregnancy País/Región como asunto: Oceania Idioma: En Revista: Proc Biol Sci Asunto de la revista: BIOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Australia

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Testosterona / Cara / Sangre Fetal Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Pregnancy País/Región como asunto: Oceania Idioma: En Revista: Proc Biol Sci Asunto de la revista: BIOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Australia