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Dichlorinated and Brominated Rugulovasines, Ergot Alkaloids Produced by Talaromyces wortmannii.
de Medeiros, Lívia Soman; da Silva, José Vinícius; Abreu, Lucas Magalhães; Pfenning, Ludwig Heinrich; Silva, Carolina Lúcia; Thomasi, Sérgio Secherrer; Venâncio, Tiago; van Pée, Karl-Heinz; Nielsen, Kristian Fog; Rodrigues-Filho, Edson.
Afiliación
  • de Medeiros LS; Department of Systems Biology, Technical University of Denmark, Søltofts Plads, Building 221, Kgs. Lyngby DK-2800, Denmark. livis@bio.dtu.dk.
  • da Silva JV; Department of Chemistry, Federal University of São Carlos, Rod. Washington Luís, Km 265, São Carlos 13565-905, Brazil. livis@bio.dtu.dk.
  • Abreu LM; Department of Chemistry, Federal University of São Carlos, Rod. Washington Luís, Km 265, São Carlos 13565-905, Brazil. zeh.vinicius@gmail.com.
  • Pfenning LH; Department of Systems Biology, Technical University of Denmark, Søltofts Plads, Building 221, Kgs. Lyngby DK-2800, Denmark. ludwig@ufla.br.
  • Silva CL; Department of Phytopathology, Federal University of Lavras, P. O. Box 3037, Lavras 37200-000, Brazil. ludwig@ufla.br.
  • Thomasi SS; Department of Phytopathology, Federal University of Lavras, P. O. Box 3037, Lavras 37200-000, Brazil. ludwig@ufla.br.
  • Venâncio T; Department of Chemistry, Federal University of São Carlos, Rod. Washington Luís, Km 265, São Carlos 13565-905, Brazil. carolina.l@hotmail.com.br.
  • van Pée KH; Department of Chemistry, Federal University of São Carlos, Rod. Washington Luís, Km 265, São Carlos 13565-905, Brazil. secherrer@yahoo.com.br.
  • Nielsen KF; Department of Chemistry, Federal University of São Carlos, Rod. Washington Luís, Km 265, São Carlos 13565-905, Brazil. venancio@ufscar.br.
  • Rodrigues-Filho E; Allgemeine Biochemie, Technical University of Dresden, Bergstraße 66, Dresden 01062, Germany. Karl-Heinz.vanPee@chemie.tu-dresden.de.
Molecules ; 20(9): 17627-44, 2015 Sep 23.
Article en En | MEDLINE | ID: mdl-26404231
UHPLC-DAD-HRMS based dereplication guided the detection of new halogenated alkaloids co-produced by Talaromyces wortmannii. From the fungal growth in large scale, the epimers 2,8-dichlororugulovasines A and B were purified and further identified by means of a HPLC-SPE/NMR hyphenated system. Brominated rugulovasines were also detected when the microbial incubation medium was supplemented with bromine sources. Studies from 1D/2D NMR and HRMS spectroscopy data allowed the structural elucidation of the dichlorinated compounds, while tandem MS/HRMS data analysis supported the rationalization of brominated congeners. Preliminary genetic studies revealed evidence that FADH2 dependent halogenase can be involved in the biosynthesis of the produced halocompounds.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Talaromyces / Indoles Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Dinamarca
Texto completo
Imprimir
XML
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Talaromyces / Indoles Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Dinamarca