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Are Anti-TNF-α Agents Safe for Treating Psoriasis in Hepatitis C Virus Patients with Advanced Liver Disease? Case Reports and Review of the Literature.
Di Nuzzo, Sergio; Boccaletti, Valeria; Fantini, Carolina; Cortelazzi, Chiara; Missale, Gabriele; Fabrizi, Giuseppe; Lotti, Torello; Hercogová, Jana; Pagliarello, Calogero.
Afiliación
  • Di Nuzzo S; Section of Dermatology, Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy.
Dermatology ; 232(1): 102-6, 2016.
Article en En | MEDLINE | ID: mdl-26444967
ABSTRACT
Tumor necrosis factor-alpha (TNF-α) inhibitors represent an effective treatment for severe psoriasis in hepatitis C virus (HCV) patients. The literature reports mainly on short-term treatment in patients with chronic hepatitis with minimum-to-moderate activity with an acceptable safety profile. We report the first 2 cases of hepatocellular carcinoma (HCC) arising in HCV psoriatic patients with advanced liver disease during long-term treatment with etanercept. Our first patient, known to have had HCV infection for 41 years, developed an HCC after 21 months of therapy with etanercept (50 mg/week). The second patient, HCV+ for 20 years, was treated for 58 months with the same therapy, and despite no signs of liver function impairment was diagnosed with HCC. Both of them presented with cirrhosis, which was diagnosed 9 and 5 years earlier, respectively. It remains to be clarified whether there is any connection between psoriasis treatment with anti-TNF-α agents and the development of HCC in HCV-infected patients. Further long-term, follow-up studies and registries of HCV patients with mild/moderate activity may contribute to clarify this issue.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Psoriasis / Factor de Necrosis Tumoral alfa / Hepatitis C Crónica / Etanercept / Inmunosupresores Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Male / Middle aged Idioma: En Revista: Dermatology Asunto de la revista: DERMATOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Psoriasis / Factor de Necrosis Tumoral alfa / Hepatitis C Crónica / Etanercept / Inmunosupresores Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Male / Middle aged Idioma: En Revista: Dermatology Asunto de la revista: DERMATOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Italia