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Anti-tumor activity of lipophilic imidazolium salts on select NSCLC cell lines.
Wright, Brian D; Deblock, Michael C; Wagers, Patrick O; Duah, Ernest; Robishaw, Nikki K; Shelton, Kerri L; Southerland, Marie R; DeBord, Michael A; Kersten, Kortney M; McDonald, Lucas J; Stiel, Jason A; Panzner, Matthew J; Tessier, Claire A; Paruchuri, Sailaja; Youngs, Wiley J.
Afiliación
  • Wright BD; Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
  • Deblock MC; Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
  • Wagers PO; Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
  • Duah E; Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
  • Robishaw NK; Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
  • Shelton KL; Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
  • Southerland MR; Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
  • DeBord MA; Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
  • Kersten KM; Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
  • McDonald LJ; Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
  • Stiel JA; Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
  • Panzner MJ; Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
  • Tessier CA; Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
  • Paruchuri S; Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
  • Youngs WJ; Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.
Med Chem Res ; 24(7): 2838-2861, 2015 Jul.
Article en En | MEDLINE | ID: mdl-26446298
ABSTRACT
The anti-tumor activity of imidazolium salts is highly dependent upon the substituents on the nitrogen atoms of the imidazolium cation. We have synthesized and characterized a series of naphthalene-substituted imidazolium salts and tested them against a variety of non-smallcell lung cancer cell lines. Several of these complexes displayed anticancer activity comparable to cisplatin. These compounds induced apoptosis in the NCI-H460 cell line as determined by Annexin V staining, caspase-3, and PARP cleavage. These results strongly suggest that this class of compounds can serve as potent chemotherapeutic agents.
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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: Med Chem Res Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: Med Chem Res Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos