Perilla frutescens Extract Ameliorates Acetylcholinesterase and Trimethyltin Chloride-Induced Neurotoxicity.
J Med Food
; 19(3): 281-9, 2016 Mar.
Article
en En
| MEDLINE
| ID: mdl-26505950
ABSTRACT
One of the critical features of Alzheimer's disease is cognitive dysfunction, which is, in part, due to decreases in acetylcholine (ACh). The ethanol extract of Perilla frutescens was selected for isolating the acetylcholinesterase (AChE) inhibitor based on preliminary screening. In vivo behavioral tests were performed to examine the effects of the P. frutescens extract on trimethyltin chloride-induced impairment of learning and memory in mice. A diet containing P. frutescens extract effectively reversed learning and memory impairment on the Y-maze and passive avoidance tests. To isolate the active compound from the P. frutescens extract, solvent partitioning, silica gel open column chromatography, thin-layer chromatography, and high-performance liquid chromatography were used. The AChE inhibitor was identified as rosmarinic acid.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Acetilcolinesterasa
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Compuestos de Trimetilestaño
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Extractos Vegetales
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Inhibidores de la Colinesterasa
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Perilla frutescens
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Enfermedad de Alzheimer
Límite:
Animals
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Humans
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Male
Idioma:
En
Revista:
J Med Food
Asunto de la revista:
CIENCIAS DA NUTRICAO
/
MEDICINA
Año:
2016
Tipo del documento:
Article