Low shear stress induces M1 macrophage polarization in murine thin-cap atherosclerotic plaques.
J Mol Cell Cardiol
; 89(Pt B): 168-72, 2015 Dec.
Article
en En
| MEDLINE
| ID: mdl-26523517
ABSTRACT
Macrophages, a significant component of atherosclerotic plaques vulnerable to acute complications, can be pro-inflammatory (designated M1), regulatory (M2), lipid- (Mox) or Heme-induced (Mhem). We showed previously that low (LSS) and oscillatory (OSS) shear stress cause thin-cap fibroatheroma and stable smooth muscle cell-rich plaque formation respectively in ApoE-knockout (ApoE(-/-)) mice. Here we investigated whether different shear stress conditions relate to specific changes in macrophage polarization and plaque morphology by applying a shear stress-altering cast to the carotid arteries of high fat-fed ApoE(-/-) mice. The M1 markers iNOS and IRF5 were highly expressed in macrophage-rich areas of LSS lesions compared to OSS lesions 6weeks after cast placement, while the M2 marker Arginase-1, and Mox/Mhem markers HO-1 and CD163 were elevated in OSS lesions. Our data indicates shear stress could be an important determinant of macrophage polarization in atherosclerosis, with low shear promoting M1 programming.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Polaridad Celular
/
Resistencia al Corte
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Placa Aterosclerótica
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Macrófagos
Límite:
Animals
Idioma:
En
Revista:
J Mol Cell Cardiol
Año:
2015
Tipo del documento:
Article
País de afiliación:
Reino Unido