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2-(Nitroaryl)benzothiazole and benzoxazole derivatives as fluorogenic substrates for the detection of nitroreductase activity in clinically important microorganisms.
Cellier, Marie; Gignoux, Amandine; James, Arthur L; Orenga, Sylvain; Perry, John D; Robinson, Shaun N; Stanforth, Stephen P; Turnbull, Graeme.
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  • Cellier M; Research & Development Microbiology, bioMérieux SA, 3 route de Port Michaud, 38 390 La-Balme-les-Grottes, France.
  • Gignoux A; Department of Applied Sciences, Northumbria University, Newcastle upon Tyne NE1 8ST, UK; École Nationale Supérieure de Chimie de Paris, 11 rue Pierre et Marie Curie, F75231 Paris Cedex 05, France.
  • James AL; Department of Applied Sciences, Northumbria University, Newcastle upon Tyne NE1 8ST, UK.
  • Orenga S; Research & Development Microbiology, bioMérieux SA, 3 route de Port Michaud, 38 390 La-Balme-les-Grottes, France.
  • Perry JD; Department of Microbiology, Freeman Hospital, Newcastle upon Tyne NE7 7DN, UK.
  • Robinson SN; Department of Applied Sciences, Northumbria University, Newcastle upon Tyne NE1 8ST, UK.
  • Stanforth SP; Department of Applied Sciences, Northumbria University, Newcastle upon Tyne NE1 8ST, UK. Electronic address: steven.stanforth@northumbria.ac.uk.
  • Turnbull G; Department of Applied Sciences, Northumbria University, Newcastle upon Tyne NE1 8ST, UK.
Bioorg Med Chem Lett ; 25(24): 5694-8, 2015 Dec 15.
Article en En | MEDLINE | ID: mdl-26547691
A series of carboxy-substituted 2-(nitroaryl)benzothiazole derivatives and carboxy-substituted 2-(nitroaryl)benzoxazole derivatives were prepared and evaluated as potential nitroreductase substrates for the purpose of detecting clinically important microorganisms. Several of the substrates produced highly fluorescent colonies with the majority of a panel of 10 Gram-negative bacteria and also with two of a panel of 8 Gram-positive bacteria.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Benzoxazoles / Nitrorreductasas / Benzotiazoles / Colorantes Fluorescentes Tipo de estudio: Diagnostic_studies Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Francia
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Benzoxazoles / Nitrorreductasas / Benzotiazoles / Colorantes Fluorescentes Tipo de estudio: Diagnostic_studies Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Francia