Technetium-99m labelled red blood cells scintigraphy and not iminodiacetic acid cholescintigraphy facilitates the discrimination of hepatic cirrhosis from fibrosis.
Hell J Nucl Med
; 18(3): 238-42, 2015.
Article
en En
| MEDLINE
| ID: mdl-26574694
ABSTRACT
OBJECTIVE:
This pilot study was designed to investigate the efficacy of technetium-99m labelled red blood cells ((99m)Tc-RBC) compared with (99m)Tc-mebrofenin cholescintigraphy ((99m)Tc-MHS), in the diagnosis of hepatic dysfunction at early stages. SUBJECTS ANDMETHODS:
Twenty four patients, 8 with hepatic fibrosis and 16 with cirrhosis, at Child-Pugh stage A to C and 20 age-matched controls were examined by (99m)Tc-RBC and by (99m)Tc-MHS. Dynamic acquisition and static images were semiquantitatively analused by studying the liver-to-heart (L/H) ratio estimated by both the (99m)Tc-RBC and (99m)Tc-MHS methods. The L/H ratios were compared between fibrosis, cirrhotic stages and controls, by Student's t test. Linear regression analysis of the L/H ratios for both methods has been applied in the whole study population.RESULTS:
Labelled RBC could statistically differentiate fibrotic from normal liver parenchyma (P<0.001), whereas the (99m)Tc-MHS could not (P 0.13). The L/H ratios of cirrhotic lesions using both methods were significantly lower than those in controls (P<0.000001 for (99m)Tc-RBC and P<0.0001 for (99m)Tc-MHS). Statistically significant difference was demonstrated by both modalities between fibrotic and cirrhotic lesions ((99m)Tc-RBC P 0.003 and (99m)Tc-MHS P 0.024).CONCLUSION:
Our study although in a limited number of patients suggested that as opposed to (99m)Tc-MHS, scintigraphic evaluation by (99m)Tc-RBC could be useful in the discrimination of patients with liver fibrosis, cirrhosis and normal controls.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Conductos Biliares
/
Compuestos de Organotecnecio
/
Tecnecio
/
Eritrocitos
/
Iminoácidos
/
Cirrosis Hepática
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Female
/
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Hell J Nucl Med
Asunto de la revista:
MEDICINA NUCLEAR
Año:
2015
Tipo del documento:
Article
País de afiliación:
Grecia