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Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies.
Townsend, Sue; Fennell, Brian J; Apgar, James R; Lambert, Matthew; McDonnell, Barry; Grant, Joanne; Wade, Jason; Franklin, Edward; Foy, Niall; Ní Shúilleabháin, Deirdre; Fields, Conor; Darmanin-Sheehan, Alfredo; King, Amy; Paulsen, Janet E; Hickling, Timothy P; Tchistiakova, Lioudmila; Cunningham, Orla; Finlay, William J J.
Afiliación
  • Townsend S; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Dublin D22, Ireland;
  • Fennell BJ; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Dublin D22, Ireland;
  • Apgar JR; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Cambridge, MA 02139;
  • Lambert M; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Dublin D22, Ireland;
  • McDonnell B; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Dublin D22, Ireland;
  • Grant J; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Dublin D22, Ireland;
  • Wade J; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Dublin D22, Ireland;
  • Franklin E; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Dublin D22, Ireland;
  • Foy N; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Dublin D22, Ireland;
  • Ní Shúilleabháin D; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Dublin D22, Ireland;
  • Fields C; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Dublin D22, Ireland;
  • Darmanin-Sheehan A; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Dublin D22, Ireland;
  • King A; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Cambridge, MA 02139;
  • Paulsen JE; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Cambridge, MA 02139;
  • Hickling TP; Pharmacokinetics, Dynamics and Metabolism, Pfizer Biotherapeutics R&D, Andover, MA 01810.
  • Tchistiakova L; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Cambridge, MA 02139;
  • Cunningham O; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Dublin D22, Ireland;
  • Finlay WJ; Global Biotherapeutics Technologies, Pfizer Biotherapeutics R&D, Dublin D22, Ireland; william.finlay@pfizer.com.
Proc Natl Acad Sci U S A ; 112(50): 15354-9, 2015 Dec 15.
Article en En | MEDLINE | ID: mdl-26621728
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Regiones Determinantes de Complementariedad / Células Germinativas / Anticuerpos Monoclonales Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2015 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Regiones Determinantes de Complementariedad / Células Germinativas / Anticuerpos Monoclonales Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2015 Tipo del documento: Article