Computational and DNMR Analysis of the Conformational Isomers and Stereodynamics of Secondary 2,2'-Bisanilides.
J Org Chem
; 81(1): 89-99, 2016 Jan 04.
Article
en En
| MEDLINE
| ID: mdl-26656940
ABSTRACT
The conformational preference of 2,2'-bisanilides was investigated by variable-temperature NMR spectroscopy, NMR titration and diffusion experiments, IR spectroscopy, computational analysis, and X-ray crystallography. The formation of a conformation having the two amide moieties linked by an intramolecular hydrogen bond was detected at low temperatures. The interconversion kinetics of the two conformational species of bisanilide 2 were determined by NMR line shape analysis. The formation of a supramolecule linked by intermolecular hydrogen bonds was ruled out by means of DMSO titration, DOSY experiments, and steric considerations.
Texto completo:
1
Bases de datos:
MEDLINE
Idioma:
En
Revista:
J Org Chem
Año:
2016
Tipo del documento:
Article
País de afiliación:
Italia