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Association of heat shock protein70-2 (HSP70-2) gene polymorphism with obesity.
Mardan-Nik, Maryam; Pasdar, Alireza; Jamialahmadi, Khadijeh; Avan, Amir; Mohebati, Mohsen; Esmaily, Habibollah; Biabangard-Zak, Atefeh; Afzal Javan, Fahimeh; Rivandi, Mahdi; Ferns, Gordon A; Ghayour-Mobarhan, Majid.
Afiliación
  • Mardan-Nik M; a Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran.
  • Pasdar A; b Department of Modern Sciences and Technologies , School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran.
  • Jamialahmadi K; c Division of Applied Medicine , Medical School, University of Aberdeen , Foresterhill , Aberdeen , UK.
  • Avan A; d Department of Medical Biotechnology , School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran.
  • Mohebati M; e Biotechnology Research Center, Mashhad University of Medical Sciences , Mashhad , Iran.
  • Esmaily H; b Department of Modern Sciences and Technologies , School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran.
  • Biabangard-Zak A; a Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran.
  • Afzal Javan F; f Department of Biostatistics and Epidemiology , School of Health, Mashhad University of Medical Sciences , Mashhad , Iran.
  • Rivandi M; g Department of Biochemistry , Golestan University , Gorgan , Iran.
  • Ferns GA; h Student Research Committee, Department of Modern Sciences & Technologies, School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran.
  • Ghayour-Mobarhan M; h Student Research Committee, Department of Modern Sciences & Technologies, School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran.
Ann Hum Biol ; 43(6): 542-546, 2016 Nov.
Article en En | MEDLINE | ID: mdl-26728972
ABSTRACT

BACKGROUND:

Obesity is a major risk factor of chronic-diseases, including cardiovascular-diseases (CVD). Increasing evidence is showing the association of heat-shock protein (HSP) with type-2 diabetes and CVD; however, there is little data on the relationship between the genetic-polymorphisms of HSP70-2 with obesity.

AIM:

The present study has investigated the association between 1267HSP70-2 genetic polymorphism and obesity in an Iranian population with 317 subjects. SUBJECTS AND

METHODS:

Anthropometric parameters and biochemical measurements were measured in all the samples, while genotypes were determined using PCR-RFLP. Univariate/multivariate analyses were conducted to explore the relationship between the genetic-polymorphisms and obesity.

RESULTS:

The data showed a significant association between 1267HSP70-2 polymorphism in obese subjects, compared to the non-obese group. Moreover, it was observed that this polymorphism was associated with obesity in the CAD + group, which had a high BMI compared to non-obese controls.

CONCLUSION:

The 1267HSP70-2 polymorphism is associated with obesity in an Iranian population, supporting a possible potential genetic link between obesity and cardiovascular diseases.
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Bases de datos: MEDLINE Asunto principal: Proteínas HSP70 de Choque Térmico / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Estudios de Asociación Genética / Obesidad Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Hum Biol Año: 2016 Tipo del documento: Article País de afiliación: Irán
Buscar en Google
Imprimir
XML
PubMed Links

Bases de datos: MEDLINE Asunto principal: Proteínas HSP70 de Choque Térmico / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Estudios de Asociación Genética / Obesidad Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Hum Biol Año: 2016 Tipo del documento: Article País de afiliación: Irán