Association of heat shock protein70-2 (HSP70-2) gene polymorphism with obesity.
Ann Hum Biol
; 43(6): 542-546, 2016 Nov.
Article
en En
| MEDLINE
| ID: mdl-26728972
ABSTRACT
BACKGROUND:
Obesity is a major risk factor of chronic-diseases, including cardiovascular-diseases (CVD). Increasing evidence is showing the association of heat-shock protein (HSP) with type-2 diabetes and CVD; however, there is little data on the relationship between the genetic-polymorphisms of HSP70-2 with obesity.AIM:
The present study has investigated the association between 1267HSP70-2 genetic polymorphism and obesity in an Iranian population with 317 subjects. SUBJECTS ANDMETHODS:
Anthropometric parameters and biochemical measurements were measured in all the samples, while genotypes were determined using PCR-RFLP. Univariate/multivariate analyses were conducted to explore the relationship between the genetic-polymorphisms and obesity.RESULTS:
The data showed a significant association between 1267HSP70-2 polymorphism in obese subjects, compared to the non-obese group. Moreover, it was observed that this polymorphism was associated with obesity in the CAD + group, which had a high BMI compared to non-obese controls.CONCLUSION:
The 1267HSP70-2 polymorphism is associated with obesity in an Iranian population, supporting a possible potential genetic link between obesity and cardiovascular diseases.Palabras clave
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Bases de datos:
MEDLINE
Asunto principal:
Proteínas HSP70 de Choque Térmico
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Predisposición Genética a la Enfermedad
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Polimorfismo de Nucleótido Simple
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Estudios de Asociación Genética
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Obesidad
Tipo de estudio:
Observational_studies
/
Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Ann Hum Biol
Año:
2016
Tipo del documento:
Article
País de afiliación:
Irán