Idiopathic Pyoderma Gangrenosum as a Novel Manifestation of the HIV Immune Reconstitution Inflammatory Syndrome: A Report of Three Cases.
J Assoc Physicians India
; 63(7): 72-6, 2015 Jul.
Article
en En
| MEDLINE
| ID: mdl-26731836
ABSTRACT
The initiation of antiretroviral treatment for individuals with HIV may be accompanied by a paradoxical flare of underlying inflammatory diseases, the recurrence of dormant infections, or worsening of prior treated opportunistic infections, termed the immune reconstitution inflammatory syndrome (IRIS). Cutaneous manifestations of IRIS are common. Pyoderma gangrenosum is a neutrophilic dermatosis postulated to reflect disrupted innate immune regulation causing altered neutrophil chemotaxis. It is uncommonly reported in association with HIV. In this case series, we present three cases of IRIS manifesting with pyoderma gangrenosum in individuals with HIV from India and the United States to raise awareness of this previously undescribed presentation and discuss the treatment challenges in the management of these patients.
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Bases de datos:
MEDLINE
Asunto principal:
Infecciones por VIH
/
Piodermia Gangrenosa
/
Síndrome Inflamatorio de Reconstitución Inmune
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Assoc Physicians India
Año:
2015
Tipo del documento:
Article