Role of microRNA-7 in digestive system malignancy.
World J Gastrointest Oncol
; 8(1): 121-7, 2016 Jan 15.
Article
en En
| MEDLINE
| ID: mdl-26798443
ABSTRACT
There are several malignancies of the digestive system (including gastric, pancreatic and colorectal cancers, and hepatocellular carcinoma), which are the most common types of cancer and a major cause of death worldwide. MicroRNA (miR)-7 is abundant in the pancreas, playing an important role in pancreatic development and endocrine function. Expression of miR-7 is downregulated in digestive system malignancies compared with normal tissue. Although there are contrasting results for miR-7 expression, almost all research reveals that miR-7 is a tumor suppressor, by targeting various genes in specific pathways. Moreover, miR-7 can target different genes simultaneously in different malignancies of the digestive system. By acting on many cytokines, miR-7 is also involved in many gastrointestinal inflammatory diseases as a significant carcinogenic factor. Consequently, miR-7 might be a biomarker or therapeutic target gene in digestive system malignancies.
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MEDLINE
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En
Revista:
World J Gastrointest Oncol
Año:
2016
Tipo del documento:
Article
País de afiliación:
China