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Mathematical PKPD and safety model of bispecific TfR/BACE1 antibodies for the optimization of antibody uptake in brain.
Gadkar, Kapil; Yadav, Daniela Bumbaca; Zuchero, Joy Yu; Couch, Jessica A; Kanodia, Jitendra; Kenrick, Margaret K; Atwal, Jasvinder K; Dennis, Mark S; Prabhu, Saileta; Watts, Ryan J; Joseph, Sean B; Ramanujan, Saroja.
Afiliación
  • Gadkar K; Preclinical and Translational Pharmacokinetics Department, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Yadav DB; Preclinical and Translational Pharmacokinetics Department, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Zuchero JY; Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Couch JA; Safety Assessment Department, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Kanodia J; Preclinical and Translational Pharmacokinetics Department, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Kenrick MK; Preclinical and Translational Pharmacokinetics Department, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Atwal JK; Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Dennis MS; Antibody Engineering Department, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Prabhu S; Preclinical and Translational Pharmacokinetics Department, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Watts RJ; Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Joseph SB; Preclinical and Translational Pharmacokinetics Department, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Ramanujan S; Preclinical and Translational Pharmacokinetics Department, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: ramanujan.saroja@gene.com.
Eur J Pharm Biopharm ; 101: 53-61, 2016 Apr.
Article en En | MEDLINE | ID: mdl-26820920
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Receptores de Transferrina / Encéfalo / Ácido Aspártico Endopeptidasas / Anticuerpos Biespecíficos / Secretasas de la Proteína Precursora del Amiloide Límite: Animals Idioma: En Revista: Eur J Pharm Biopharm Asunto de la revista: FARMACIA / FARMACOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Receptores de Transferrina / Encéfalo / Ácido Aspártico Endopeptidasas / Anticuerpos Biespecíficos / Secretasas de la Proteína Precursora del Amiloide Límite: Animals Idioma: En Revista: Eur J Pharm Biopharm Asunto de la revista: FARMACIA / FARMACOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos