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Tenofovir alafenamide as part of a salvage regimen in a patient with multi-drug resistant HIV and tenofovir-DF-associated renal tubulopathy.
Mikula, James M; Manion, Maura M; Maldarelli, Frank; Suarez, Lucila M; Norman-Wheeler, Jaha F; Ober, Alex G; Dewar, Robin L; Kopp, Jeffrey B; Lane, H Clifford; Pau, Alice K.
Afiliación
  • Mikula JM; Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Manion MM; National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
  • Maldarelli F; HIV Drug Resistance Program, National Cancer Institute, Bethesda, MD, USA.
  • Suarez LM; National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
  • Norman-Wheeler JF; Clinical Center, NIH, Bethesda, MD, USA.
  • Ober AG; National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
  • Dewar RL; Applied and Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Kopp JB; National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.
  • Lane HC; National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
  • Pau AK; National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Antivir Ther ; 21(6): 553-558, 2016.
Article en En | MEDLINE | ID: mdl-26954372
ABSTRACT
We describe a patient with two recent episodes of tenofovir disoproxil fumarate (TDF)-associated acute kidney injury and six-class drug-resistant HIV infection who achieved and maintained viral suppression without worsening kidney function on a regimen including tenofovir alafenamide (TAF) through 48 weeks of therapy. The safety and efficacy of TAF in patients with TDF-associated renal tubulopathy and multiple drug resistant HIV has not yet been described. TAF may represent a useful option to maximally suppress HIV in patients with these complications.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Adenina / Infecciones por VIH / Fármacos Anti-VIH / Lesión Renal Aguda / Tenofovir Tipo de estudio: Risk_factors_studies Límite: Humans / Male / Middle aged Idioma: En Revista: Antivir Ther Asunto de la revista: TERAPIA POR MEDICAMENTOS / VIROLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Adenina / Infecciones por VIH / Fármacos Anti-VIH / Lesión Renal Aguda / Tenofovir Tipo de estudio: Risk_factors_studies Límite: Humans / Male / Middle aged Idioma: En Revista: Antivir Ther Asunto de la revista: TERAPIA POR MEDICAMENTOS / VIROLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos