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Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations.
Jensen, Niels Frank; Agama, Keli; Roy, Amit; Smith, David Hersi; Pfister, Thomas D; Rømer, Maria Unni; Zhang, Hong-Liang; Doroshow, James H; Knudsen, Birgitta R; Stenvang, Jan; Brünner, Nils; Pommier, Yves.
Afiliación
  • Jensen NF; Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, Section for Molecular Disease Biology, University of Copenhagen, Strandboulevarden 49, DK-2100, Copenhagen, Denmark.
  • Agama K; National Institutes of Health, National Cancer Institute, Center for Cancer Research, Laboratory of Molecular Pharmacology, 37 Convent Drive, Building 37, Room 5068, Bethesda, MD, 20892-4255, USA.
  • Roy A; Department of Molecular Biology and Genetics, Aarhus University, C.F. Møllers Allé 3, Building 1130, DK-8000, Aarhus C, Denmark.
  • Smith DH; Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Hajipur, Vaishali, 844102, India.
  • Pfister TD; Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, Section for Molecular Disease Biology, University of Copenhagen, Strandboulevarden 49, DK-2100, Copenhagen, Denmark.
  • Rømer MU; Dako Denmark A/S, R&D, Produktionsvej 42, DK-2600, Glostrup, Denmark.
  • Zhang HL; Laboratory of Human Toxicology and Pharmacology, Applied/Developmental Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA.
  • Doroshow JH; Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, Section for Molecular Disease Biology, University of Copenhagen, Strandboulevarden 49, DK-2100, Copenhagen, Denmark.
  • Knudsen BR; Department for Clinical Physiology and Nuclear Medicine, Frederiksberg Hospital, Nordre Fasanvej 57, DK-2000, Frederiksberg C, Denmark.
  • Stenvang J; National Institutes of Health, National Cancer Institute, Center for Cancer Research, Laboratory of Molecular Pharmacology, 37 Convent Drive, Building 37, Room 5068, Bethesda, MD, 20892-4255, USA.
  • Brünner N; National Institutes of Health, National Cancer Institute, Center for Cancer Research, Laboratory of Molecular Pharmacology, 37 Convent Drive, Building 37, Room 5068, Bethesda, MD, 20892-4255, USA.
  • Pommier Y; Laboratory of Human Toxicology and Pharmacology, Applied/Developmental Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA.
J Exp Clin Cancer Res ; 35: 56, 2016 Mar 31.
Article en En | MEDLINE | ID: mdl-27029323
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Camptotecina / Neoplasias del Colon / ADN-Topoisomerasas de Tipo I / Resistencia a Antineoplásicos / Mutación Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Exp Clin Cancer Res Año: 2016 Tipo del documento: Article País de afiliación: Dinamarca
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Camptotecina / Neoplasias del Colon / ADN-Topoisomerasas de Tipo I / Resistencia a Antineoplásicos / Mutación Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Exp Clin Cancer Res Año: 2016 Tipo del documento: Article País de afiliación: Dinamarca