Curcumin-loaded silica-based mesoporous materials: Synthesis, characterization and cytotoxic properties against cancer cells.
Mater Sci Eng C Mater Biol Appl
; 63: 393-410, 2016 Jun.
Article
en En
| MEDLINE
| ID: mdl-27040234
ABSTRACT
Two different silica based (MSU-2 and MCM-41) curcumin loaded mesoporous materials V3 and V6 were synthesized and characterized by several physico-chemical techniques. Release kinetic study revealed the slow and sustained release of curcumin from those materials in blood simulated fluid (pH 7.4). The materials V3 and V6 were found to be biocompatible in non-cancerous CHO cell line while exhibiting significant cytotoxicity in different cancer cells (human lung carcinoma cells A549, human breast cancer cells MCF-7, mouse melanoma cells B16F10) compared to pristine curcumin indicating the efficacy of the mesoporous silica materials based drug delivery systems (DDSs). The generation of intracellular reactive oxygen species (ROS) and down regulation of anti-apoptotic protein leading to the induction of apoptosis were found to be the plausible mechanisms behind the anti-cancer activity of these DDSs. These results suggest that curcumin-loaded drug delivery system may be successfully employed as an alternative treatment strategy for cancer therapeutics through a nanomedicine approach in near future.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Portadores de Fármacos
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Dióxido de Silicio
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Curcumina
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Antineoplásicos
Límite:
Animals
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Humans
Idioma:
En
Revista:
Mater Sci Eng C Mater Biol Appl
Año:
2016
Tipo del documento:
Article
País de afiliación:
India