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Post-mortem findings in a patient with avian influenza A (H5N6) virus infection.
Gao, R; Pan, M; Li, X; Zou, X; Zhao, X; Li, T; Yang, H; Zou, S; Bo, H; Xu, J; Li, S; Zhang, M; Li, Z; Wang, D; Zaki, S R; Shu, Y.
Afiliación
  • Gao R; National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China.
  • Pan M; Sichuan Provincial Disease Control and Prevention, Chengdu, China.
  • Li X; National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China.
  • Zou X; National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China.
  • Zhao X; National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China.
  • Li T; Sichuan Provincial Disease Control and Prevention, Chengdu, China.
  • Yang H; Sichuan Provincial Disease Control and Prevention, Chengdu, China.
  • Zou S; National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China.
  • Bo H; National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China.
  • Xu J; Sichuan Provincial Disease Control and Prevention, Chengdu, China.
  • Li S; Sichuan Provincial Disease Control and Prevention, Chengdu, China.
  • Zhang M; Nanchong City Disease Control and Prevention, Nanchong, China.
  • Li Z; Affiliated Hospital of Chuanbei Medical School, Nanchong, China.
  • Wang D; National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China.
  • Zaki SR; Infectious Diseases Pathology Branch, Division of High-consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Shu Y; National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, China. Electronic address: yshu@cnic.org.cn.
Clin Microbiol Infect ; 22(6): 574.e1-5, 2016 Jun.
Article en En | MEDLINE | ID: mdl-27040806
ABSTRACT
Avian influenza A (H5N6) has been found to infect humans, and has resulted in ten cases with six deaths in China since 2014. Here, we describe the systematic post-mortem pathology of a patient fatally infected with H5N6 virus and evaluate the associated pathogenesis compared with H1N1 pdm09 fatal cases. The most prominent histopathological features were diffuse alveolar damage and pulmonary vasculitis in the lungs of the patient. The virus disseminated to extrapulmonary organs, including the brain. Compared with H1N1 pdm09 fatal infection, H5N6 infection induced a more exacerbated immune response involving overt pulmonary inflammation, which led to alveolar damage and respiratory failure.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Virus de la Influenza A / Autopsia / Glicoproteínas Hemaglutininas del Virus de la Influenza / Gripe Humana / Neuraminidasa Tipo de estudio: Diagnostic_studies Límite: Animals / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Clin Microbiol Infect Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Virus de la Influenza A / Autopsia / Glicoproteínas Hemaglutininas del Virus de la Influenza / Gripe Humana / Neuraminidasa Tipo de estudio: Diagnostic_studies Límite: Animals / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Clin Microbiol Infect Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: China