The Effect of Topical Diquafosol Tetrasodium 3% on Dry Eye After Cataract Surgery.
Curr Eye Res
; 41(10): 1281-1285, 2016 10.
Article
en En
| MEDLINE
| ID: mdl-27049809
ABSTRACT
PURPOSE:
To evaluate the effectiveness of 3% diquafosol tetrasodium for treating dry eye after cataract surgery.METHODS:
Among patients who underwent bilateral cataract surgery, 34, who met the diagnostic criteria for dry eye syndrome 1 week postoperatively, were enrolled. Patients were randomly assigned to receive 3.0% diquafosol tetrasodium ophthalmic solution in one eye and 0.9% saline in the other eye four times daily for 8 weeks. Dry eye severity was measured at 1, 5, and 9 postoperative weeks using the Schirmer 1 test (SIT), tear film breakup time (TBUT), and fluorescein corneal staining. tear meniscus height (TMH), tear meniscus depth (TMD), and tear meniscus area (TMA) measured using Fourier-domain optical coherence tomography and symptom questionnaire scores.RESULTS:
TBUT and corneal staining significantly improved 8 weeks postoperatively in eyes treated with 3.0% diquafosol tetrasodium (p < 0.01, p < 0.01) and were better than normal saline-treated eyes (p < 0.01, p < 0.01). SIT did not improve (p = 0.26). TMH, TMD, and TMA did not improve at 4 and 8 weeks. All symptom questionnaire scores improved in eyes treated with 3.0% diquafosol tetrasodium (all p < 0.01).CONCLUSION:
The 3.0% diquafosol tetrasodium treatment improved tear film stability and subjective symptoms of dry eye after cataract surgery. Increased mucin production as a result of diquafosol treatment may have caused these results.Palabras clave
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Bases de datos:
MEDLINE
Asunto principal:
Polifosfatos
/
Complicaciones Posoperatorias
/
Lágrimas
/
Nucleótidos de Uracilo
/
Síndromes de Ojo Seco
/
Extracción de Catarata
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Curr Eye Res
Año:
2016
Tipo del documento:
Article