Seminal HIV-1 RNA Detection in Heterosexual African Men Initiating Antiretroviral Therapy.
J Infect Dis
; 214(2): 212-5, 2016 07 15.
Article
en En
| MEDLINE
| ID: mdl-27053765
ABSTRACT
BACKGROUND:
Intermittent shedding of human immunodeficiency virus type 1 (HIV) in semen occurs despite effective antiretroviral therapy (ART) and suppressed blood HIV-1 RNA levels.METHODS:
We assessed the frequency, magnitude, and correlates of seminal HIV-1 RNA shedding in HIV-1-infected African men initiating ART.RESULTS:
Seminal HIV-1 RNA was detected in 24% (37 of 155), 10% (5 of 49), and 11% (8 of 70) of samples collected 0-3, 4-6, and >6 months after ART initiation. When blood HIV-1 levels were suppressed, seminal HIV-1 RNA was detected in 8% (16 of 195), and 82% (13 of 16) had an HIV-1 RNA load of < 1000 copies/mL.CONCLUSIONS:
Seminal HIV-1 RNA shedding was infrequent and present at low levels in HIV-1-infected African men with suppressed blood HIV-1 RNA.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Semen
/
ARN Viral
/
Infecciones por VIH
/
Esparcimiento de Virus
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
Límite:
Adult
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
Africa
Idioma:
En
Revista:
J Infect Dis
Año:
2016
Tipo del documento:
Article