PepComposer: computational design of peptides binding to a given protein surface.
Nucleic Acids Res
; 44(W1): W522-8, 2016 07 08.
Article
en En
| MEDLINE
| ID: mdl-27131789
ABSTRACT
There is a wide interest in designing peptides able to bind to a specific region of a protein with the aim of interfering with a known interaction or as starting point for the design of inhibitors. Here we describe PepComposer, a new pipeline for the computational design of peptides binding to a given protein surface. PepComposer only requires the target protein structure and an approximate definition of the binding site as input. We first retrieve a set of peptide backbone scaffolds from monomeric proteins that harbor the same backbone arrangement as the binding site of the protein of interest. Next, we design optimal sequences for the identified peptide scaffolds. The method is fully automatic and available as a web server at http//biocomputing.it/pepcomposer/webserver.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Péptidos
/
Programas Informáticos
/
Proteínas
/
Diseño Asistido por Computadora
Tipo de estudio:
Health_economic_evaluation
/
Prognostic_studies
Idioma:
En
Revista:
Nucleic Acids Res
Año:
2016
Tipo del documento:
Article
País de afiliación:
Italia