XLinkDB 2.0: integrated, large-scale structural analysis of protein crosslinking data.
Bioinformatics
; 32(17): 2716-8, 2016 09 01.
Article
en En
| MEDLINE
| ID: mdl-27153666
ABSTRACT
MOTIVATION Large-scale chemical cross-linking with mass spectrometry (XL-MS) analyses are quickly becoming a powerful means for high-throughput determination of protein structural information and protein-protein interactions. Recent studies have garnered thousands of cross-linked interactions, yet the field lacks an effective tool to compile experimental data or access the network and structural knowledge for these large scale analyses. We present XLinkDB 2.0 which integrates tools for network analysis, Protein Databank queries, modeling of predicted protein structures and modeling of docked protein structures. The novel, integrated approach of XLinkDB 2.0 enables the holistic analysis of XL-MS protein interaction data without limitation to the cross-linker or analytical system used for the analysis. AVAILABILITY AND IMPLEMENTATION XLinkDB 2.0 can be found here, including documentation and help http//xlinkdb.gs.washington.edu/ CONTACT jimbruce@uw.edu SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Conformación Proteica
/
Programas Informáticos
/
Proteínas
/
Bases de Datos de Proteínas
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Bioinformatics
Asunto de la revista:
INFORMATICA MEDICA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos