Interior tomographic imaging of mouse heart in a carbon nanotube micro-CT.
J Xray Sci Technol
; 24(4): 549-63, 2016 05 02.
Article
en En
| MEDLINE
| ID: mdl-27163376
ABSTRACT
BACKGROUND:
The relatively high radiation dose from micro-CT is a cause for concern in preclinical research involving animal subjects. Interior region-of-interest (ROI) imaging was proposed for dose reduction, but has not been experimentally applied in micro-CT.OBJECTIVE:
Our aim is to implement interior ROI imaging in a carbon nanotube (CNT) x-ray source based micro-CT, and present the ROI image quality and radiation dose reduction for interior cardiac micro-CT imaging of a mouse heart in situ.METHODS:
An aperture collimator was mounted at the source-side to induce a small-sized cone beam (10âmm width) at the isocenter. Interior in situ micro-CT scans were conducted on a mouse carcass and several micro-CT phantoms. A GPU-accelerated hybrid iterative reconstruction algorithm was employed for volumetric image reconstruction. Radiation dose was measured for the same system operated at the interior and global micro-CT modes.RESULTS:
Visual inspection demonstrated comparable image quality between two scan modes. Quantitative evaluation demonstrated high structural similarity index (up to 0.9614) with improved contrast-noise-ratio (CNR) on interior micro-CT mode. Interior micro-CT mode yielded significant reduction (up to 83.9%) for dose length product (DLP).CONCLUSIONS:
This work demonstrates the applicability of using CNT x-ray source based interior micro-CT for preclinical imaging with significantly reduced radiation dose.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Procesamiento de Imagen Asistido por Computador
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Nanotubos de Carbono
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Microtomografía por Rayos X
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Corazón
Límite:
Animals
Idioma:
En
Revista:
J Xray Sci Technol
Asunto de la revista:
RADIOLOGIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos