V-akt murine thymoma viral oncogene homolog 3 (AKT3) contributes to poor disease outcome in humans and mice with pneumococcal meningitis.

Valls Serón, Mercedes; Ferwerda, Bart; Engelen-Lee, JooYeon; Geldhoff, Madelijn; Jaspers, Valery; Zwinderman, Aeilko H; Tanck, Michael W; Baas, Frank; van der Ende, Arie; Brouwer, Matthijs C; van de Beek, Diederik

Valls Serón, Mercedes; Ferwerda, Bart; Engelen-Lee, JooYeon; Geldhoff, Madelijn; Jaspers, Valery; Zwinderman, Aeilko H; Tanck, Michael W; Baas, Frank; van der Ende, Arie; Brouwer, Matthijs C; van de Beek, Diederik.

Afiliación

Valls Serón M; Department of Neurology, Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, P.O. Box 22660, 1100DD, Amsterdam, The Netherlands.
Ferwerda B; Department of Neurology, Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, P.O. Box 22660, 1100DD, Amsterdam, The Netherlands.
Engelen-Lee J; Department of Neurology, Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, P.O. Box 22660, 1100DD, Amsterdam, The Netherlands.
Geldhoff M; Department of Neurology, Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, P.O. Box 22660, 1100DD, Amsterdam, The Netherlands.
Jaspers V; Department of Neurology, Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, P.O. Box 22660, 1100DD, Amsterdam, The Netherlands.
Zwinderman AH; Department of Clinical Epidemiology, Biostatistics, and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Tanck MW; Department of Clinical Epidemiology, Biostatistics, and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Baas F; Department of Genome Analysis, Academic Medical Center, Amsterdam, The Netherlands.
van der Ende A; Department of Medical Microbiology, Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands.
Brouwer MC; The Netherlands Reference Laboratory for Bacterial Meningitis, Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands.
van de Beek D; Department of Neurology, Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, P.O. Box 22660, 1100DD, Amsterdam, The Netherlands.

Acta Neuropathol Commun ; 4(1): 50, 2016 05 18.

Article en En | MEDLINE | ID: mdl-27193124

Asunto(s)

Predisposición Genética a la Enfermedad; Meningitis Neumocócica/genética; Proteínas Proto-Oncogénicas c-akt/genética; Animales; Proteínas Portadoras/genética; Citocinas/líquido cefalorraquídeo; Modelos Animales de Enfermedad; Complejo Dinactina/genética; Estudios de Asociación Genética; Antígenos de Histocompatibilidad Clase I/genética; Humanos; Masculino; Proteínas de la Membrana/genética; Meningitis Neumocócica/metabolismo; Meningitis Neumocócica/patología; Meningitis Neumocócica/terapia; Ratones Endogámicos C57BL; Ratones Noqueados; Persona de Mediana Edad; Países Bajos; Estudios Prospectivos; Proteínas Proto-Oncogénicas c-akt/deficiencia; Análisis de Supervivencia; Resultado del Tratamiento

Palabras clave

AKT3; Bacterial meningitis; Prospective nationwide genetic association study; Streptococcus pneumoniae

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Predisposición Genética a la Enfermedad / Proteínas Proto-Oncogénicas c-akt / Meningitis Neumocócica Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Acta Neuropathol Commun Año: 2016 Tipo del documento: Article País de afiliación: Países Bajos

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google