Thermal regulation of FMLP receptors on human neutrophils.
J Leukoc Biol
; 45(6): 529-37, 1989 Jun.
Article
en En
| MEDLINE
| ID: mdl-2723537
ABSTRACT
Polymorphonuclear leukocytes (PMNs) from subjects diagnosed as having juvenile periodontitis (JP) have been categorized on the basis of their chemotactic (CTX) response to f-met-leu-phe (FMLP) when assayed concurrently with PMNs from periodontally healthy subjects (HP). When PMNs from JP groups demonstrating depressed CTX were assayed for lysosomal enzyme secretion (LES) in response to FMLP, there were no significant differences with respect to rate or amount. Significant differences were observed between HP and chemotactically depressed JP cells when assessed for FMLP receptor ligand binding at 23 degrees C, but not at 4 degrees C. Receptor differences observed at 23 degrees C in HP cells included an increase in amount of total binding, number of receptors, and available displaceable binding sites, compared with the chemotactically depressed JP PMNs, whereas the receptor affinities were similar. These data suggest that differences in FMLP receptor density in JP PMN that are chemotactically depressed may be related to processes that modulate receptor mobility and/or expression.
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Bases de datos:
MEDLINE
Asunto principal:
Receptores Inmunológicos
/
Neutrófilos
Límite:
Humans
Idioma:
En
Revista:
J Leukoc Biol
Año:
1989
Tipo del documento:
Article