Exposure to endocrine disrupting chemicals and neurodevelopmental alterations.
Andrology
; 4(4): 706-22, 2016 07.
Article
en En
| MEDLINE
| ID: mdl-27285165
ABSTRACT
The developing brain is remarkably malleable as neural circuits are formed and these circuits are strongly dependent on hormones for their development. For those reasons, the brain is very vulnerable to the effects of endocrine-disrupting chemicals (EDCs) during critical periods of development. This review focuses on three ubiquitous endocrine disruptors that are known to disrupt the thyroid function and are associated with neurobehavioral deficits polychlorinated biphenyls, polybrominated diphenyl ethers, and bisphenol A. The human and rodent data suggesting effects of those EDCs on memory, cognition, and social behavior are discussed. Their mechanisms of action go beyond relative hypothyroidism with effects on neurotransmitter release and calcium signaling.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Glándula Tiroides
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Cognición
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Exposición a Riesgos Ambientales
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Disruptores Endocrinos
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Memoria
Límite:
Animals
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Humans
Idioma:
En
Revista:
Andrology
Año:
2016
Tipo del documento:
Article
País de afiliación:
Bélgica