Signaling Networks Determining Life Span.
Annu Rev Biochem
; 85: 35-64, 2016 Jun 02.
Article
en En
| MEDLINE
| ID: mdl-27294438
ABSTRACT
The health of an organism is orchestrated by a multitude of molecular and biochemical networks responsible for ensuring homeostasis within cells and tissues. However, upon aging, a progressive failure in the maintenance of this homeostatic balance occurs in response to a variety of endogenous and environmental stresses, allowing the accumulation of damage, the physiological decline of individual tissues, and susceptibility to diseases. What are the molecular and cellular signaling events that control the aging process and how can this knowledge help design therapeutic strategies to combat age-associated diseases? Here we provide a comprehensive overview of the evolutionarily conserved biological processes that alter the rate of aging and discuss their link to disease prevention and the extension of healthy life span.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Daño del ADN
/
Transducción de Señal
/
Deficiencias en la Proteostasis
/
Acortamiento del Telómero
/
Longevidad
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Annu Rev Biochem
Año:
2016
Tipo del documento:
Article