Functional interdependence of BRD4 and DOT1L in MLL leukemia.

Gilan, Omer; Lam, Enid Y N; Becher, Isabelle; Lugo, Dave; Cannizzaro, Ester; Joberty, Gerard; Ward, Aoife; Wiese, Meike; Fong, Chun Yew; Ftouni, Sarah; Tyler, Dean; Stanley, Kym; MacPherson, Laura; Weng, Chen-Fang; Chan, Yih-Chih; Ghisi, Margherita; Smil, David; Carpenter, Christopher; Brown, Peter; Garton, Neil; Blewitt, Marnie E; Bannister, Andrew J; Kouzarides, Tony; Huntly, Brian J P; Johnstone, Ricky W; Drewes, Gerard; Dawson, Sarah-Jane; Arrowsmith, Cheryl H; Grandi, Paola; Prinjha, Rab K; Dawson, Mark A

Gilan, Omer; Lam, Enid Y N; Becher, Isabelle; Lugo, Dave; Cannizzaro, Ester; Joberty, Gerard; Ward, Aoife; Wiese, Meike; Fong, Chun Yew; Ftouni, Sarah; Tyler, Dean; Stanley, Kym; MacPherson, Laura; Weng, Chen-Fang; Chan, Yih-Chih; Ghisi, Margherita; Smil, David; Carpenter, Christopher; Brown, Peter; Garton, Neil; Blewitt, Marnie E; Bannister, Andrew J; Kouzarides, Tony; Huntly, Brian J P; Johnstone, Ricky W; Drewes, Gerard; Dawson, Sarah-Jane; Arrowsmith, Cheryl H; Grandi, Paola; Prinjha, Rab K; Dawson, Mark A.

Afiliación

Gilan O; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Lam EY; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.
Becher I; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Lugo D; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.
Cannizzaro E; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline, Heidelberg, Germany.
Joberty G; Epinova DPU, Immuno-Inflammation Therapy Area Unit, GlaxoSmithKline, Stevenage, UK.
Ward A; The Gurdon Institute, University of Cambridge, Cambridge, UK.
Wiese M; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline, Heidelberg, Germany.
Fong CY; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline, Heidelberg, Germany.
Ftouni S; The Gurdon Institute, University of Cambridge, Cambridge, UK.
Tyler D; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Stanley K; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.
MacPherson L; Department of Haematology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Weng CF; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Chan YC; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Ghisi M; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.
Smil D; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Carpenter C; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Brown P; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Garton N; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Blewitt ME; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Bannister AJ; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
Kouzarides T; Cancer Epigenetics DPU, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
Huntly BJ; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
Johnstone RW; Epinova DPU, Immuno-Inflammation Therapy Area Unit, GlaxoSmithKline, Stevenage, UK.
Drewes G; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Dawson SJ; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.
Arrowsmith CH; The Gurdon Institute, University of Cambridge, Cambridge, UK.
Grandi P; The Gurdon Institute, University of Cambridge, Cambridge, UK.
Prinjha RK; Department of Haematology, Cambridge Institute for Medical Research, Cambridge, UK.
Dawson MA; Cambridge Stem Cell Institute, Cambridge, UK.

Nat Struct Mol Biol ; 23(7): 673-81, 2016 07.

Article en En | MEDLINE | ID: mdl-27294782

Asunto(s)

Regulación Leucémica de la Expresión Génica; Histonas/genética; Leucemia Bifenotípica Aguda/genética; Metiltransferasas/genética; Proteínas Nucleares/genética; Factores de Transcripción/genética; Acetilación; Animales; Linfocitos B/metabolismo; Linfocitos B/patología; Proteínas de Ciclo Celular; Proliferación Celular; Cromatina/química; Cromatina/metabolismo; Ensayos Clínicos como Asunto; Modelos Animales de Enfermedad; Femenino; N-Metiltransferasa de Histona-Lisina; Histonas/metabolismo; Humanos; Leucemia Bifenotípica Aguda/metabolismo; Leucemia Bifenotípica Aguda/patología; Masculino; Metiltransferasas/antagonistas & inhibidores; Metiltransferasas/metabolismo; Ratones; Ratones Endogámicos C57BL; Proteínas Nucleares/antagonistas & inhibidores; Proteínas Nucleares/metabolismo; Cultivo Primario de Células; Unión Proteica; Proteómica/métodos; ARN Interferente Pequeño/genética; ARN Interferente Pequeño/metabolismo; Transducción de Señal; Linfocitos T/metabolismo; Linfocitos T/patología; Factores de Transcripción/antagonistas & inhibidores; Factores de Transcripción/metabolismo; Transcripción Genética

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Factores de Transcripción / Proteínas Nucleares / Histonas / Leucemia Bifenotípica Aguda / Regulación Leucémica de la Expresión Génica / Metiltransferasas Tipo de estudio: Prognostic_studies Idioma: En Revista: Nat Struct Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2016 Tipo del documento: Article País de afiliación: Australia

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