c-MYC partners with BPTF in human cancer.
Mol Cell Oncol
; 3(3): e1152346, 2016 May.
Article
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| MEDLINE
| ID: mdl-27314097
ABSTRACT
The c-MYC oncogene is deregulated in virtually all human tumors and therefore constitutes an attractive therapeutic target. We found that the chromatin remodeler BPTF is a c-MYC interactor required for c-MYC chromatin recruitment and transcriptional activity. Moreover, inhibition of BPTF delays tumor development both in vitro and in vivo and its levels positively correlate with c-MYC signatures in human tumors. We propose BPTF as a therapeutic target in c-MYC-addicted tumors.
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MEDLINE
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En
Revista:
Mol Cell Oncol
Año:
2016
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Article
País de afiliación:
España