Tongue squamous cell carcinoma producing both parathyroid hormone-related protein and granulocyte colony-stimulating factor: a case report and literature review.
World J Surg Oncol
; 14(1): 161, 2016 Jun 17.
Article
en En
| MEDLINE
| ID: mdl-27316348
ABSTRACT
BACKGROUND:
Paraneoplastic syndrome generally results from tumor-derived hormones or peptides that cause metabolic derangements. Common metabolic conditions include hyponatremia, hypercalcemia, hypoglycemia, and Cushing's syndrome. Herein, we report a very rare case of tongue carcinoma presenting with leukocytosis and hypercalcemia. CASE PRESENTATION A 57-year-old man was admitted to our hospital with tongue squamous cell carcinoma (cT4aN0M0, stage IV). He underwent radical resection following preoperative chemoradiotherapy, but locoregional recurrence was detected 2 months after surgery. He presented with marked leukocytosis and hypercalcemia with elevated serum levels of granulocyte colony-stimulating factor (G-CSF) and parathyroid hormone-related protein (PTHrP). He was therefore managed with intravenous fluids, furosemide, prednisolone, elcatonin, and pamidronate. However, the patient died 1 month later of carcinomatous pleuritis following distant metastasis to the lung. Immunohistochemical analyses of the resected specimens revealed positive staining for PTHrP and G-CSF in the cancer cells.CONCLUSIONS:
In this case, it was considered that tumor-derived G-CSF and PTHrP caused leukocytosis and hypercalcemia.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Neoplasias de la Lengua
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Carcinoma de Células Escamosas
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Factor Estimulante de Colonias de Granulocitos
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Proteína Relacionada con la Hormona Paratiroidea
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Hipercalcemia
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Leucocitosis
Límite:
Humans
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Male
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Middle aged
Idioma:
En
Revista:
World J Surg Oncol
Año:
2016
Tipo del documento:
Article
País de afiliación:
Japón